Document Detail


Treatment with pharmacological agents in peripheral arterial disease patients does not result in biomechanical gait changes.
MedLine Citation:
PMID:  20841626     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pharmacological treatment has been used to alleviate the claudication symptoms and improve walking performance in peripheral arterial disease (PAD) patients. However, the effects of claudication treatments on gait mechanics have not been objectively identified with biomechanical techniques. For this study, 20 PAD patients were assigned to take either pentoxifylline (n=11) or cilostazol (n=9), the two FDA-approved pharmacological therapies used to treat intermittent claudication symptoms. All patients completed a gait evaluation protocol that involved the acquisition of kinematic and kinetic gait data before use of the medication and after 12 weeks of treatment. Results showed that treatment with either pentoxifylline or cilostazol resulted in limited overall improvement in gait parameters including joint angles and joint moments. Walking speed was unchanged, in either treatment group, as a result of the medication. These results suggest that to improve biomechanical walking parameters of PAD patients, clinicians cannot rely on drug therapies alone.
Authors:
Jessie M Huisinga; Iraklis I Pipinos; Nicholas Stergiou; Jason M Johanning
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of applied biomechanics     Volume:  26     ISSN:  1065-8483     ISO Abbreviation:  J Appl Biomech     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-09-15     Completed Date:  2010-11-02     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  9315240     Medline TA:  J Appl Biomech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  341-8     Citation Subset:  IM    
Affiliation:
Nebraska Biomechanics Core Facility, Department of Health, Physical Education, and Recreation, University of Nebraska at Omaha, Omaha, NE, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Analysis of Variance
Biomechanics
Female
Gait / drug effects*
Humans
Imaging, Three-Dimensional
Intermittent Claudication / drug therapy*
Male
Pain Measurement
Pentoxifylline / therapeutic use*
Peripheral Vascular Diseases / drug therapy*
Tetrazoles / therapeutic use*
Treatment Outcome
Vasodilator Agents / therapeutic use*
Grant Support
ID/Acronym/Agency:
K25HD047194/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Tetrazoles; 0/Vasodilator Agents; 6493-05-6/Pentoxifylline; N7Z035406B/cilostazol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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