Document Detail

Treatment with nesiritide, a recombinant B-type natriuretic Peptide, reduces vascular remodeling following balloon-induced endothelial injuries in rabbits.
MedLine Citation:
PMID:  21079380     Owner:  NLM     Status:  MEDLINE    
Re-stenosis or remodeling of coronary and peripheral arteries remains a major complication following balloon-angioplasty or stenting. This study was designed to investigate the effect of nesiritide, a recombinant B-type natriuretic peptide (BNP), on vascular remodeling following balloon-induced endothelial injuries. Twenty-eight male New Zealand rabbits were divided into nesiritide-treated (0.1 mg/kg/day, sc, for 4 weeks, n = 10), saline-treated control (n = 10) and sham-operated groups (n = 8). In the nesiritide and control groups, a balloon catheter was inserted to the right iliac artery to induce injuries. Vascular endothelial growth factor (VEGF) was measured by immunohistochemistry. The area under internal elastic membrane of the arterial wall (643.2 ± 134.1 vs 493.7 ± 139.3 µm(2), p < 0.05) and the area under external elastic membrane (1495.1 ± 204.9 vs 1265.9 ± 232.6 µm(2), p < 0.05) in the nesiritide group were greater than those in the control group, but were smaller than those in the sham-operated group (p < 0.05). The stenosis ratio was lower in the nesiritide group than in the control group (18.7 ± 7.7% vs 38.0 ± 8.3%, p < 0.01). Importantly, the VEGF expression rate was significantly lower in the nesiritide group than in the control group (42.2 ± 8.8% vs 56.1 ± 13.1%, p < 0.05), while there were no signs of VEGF expression in the non-injured arteries of the three groups. In conclusion, nesiritide treatment reduces the stenosis of the rabbit iliac artery following balloon-induced endothelial injuries probably by decreasing VEGF expression.
Shu-Qin Liu; Yan-Yun Yu; Hong-Wen Xie; Ke Yu; Le-Xin Wang
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  222     ISSN:  1349-3329     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-16     Completed Date:  2011-02-17     Revised Date:  2013-01-03    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  219-23     Citation Subset:  IM    
Department of Cardiology, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Shandong, PR China.
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MeSH Terms
Angioplasty, Balloon / adverse effects*
Blood Vessels / drug effects*,  injuries,  pathology,  physiology
Constriction, Pathologic / drug therapy,  etiology,  metabolism,  pathology
Drug Evaluation, Preclinical
Endothelium, Vascular / drug effects*,  metabolism,  pathology
Iliac Artery / drug effects,  injuries,  metabolism,  pathology
Natriuretic Agents / pharmacology,  therapeutic use
Natriuretic Peptide, Brain / analogs & derivatives,  pharmacology,  therapeutic use*
Recombinant Proteins / pharmacology,  therapeutic use
Vascular Diseases / drug therapy*,  etiology*,  metabolism,  pathology
Vascular Endothelial Growth Factor A / metabolism
Reg. No./Substance:
0/Natriuretic Agents; 0/Recombinant Proteins; 0/Vascular Endothelial Growth Factor A; 114471-18-0/Natriuretic Peptide, Brain

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