Document Detail

Treatment with ferulic acid to rats with streptozotocin-induced diabetes: effects on oxidative stress, pro-inflammatory cytokines, and apoptosis in the pancreatic β cell.
MedLine Citation:
PMID:  23299178     Owner:  NLM     Status:  Publisher    
In the present study, we aimed to investigate the protective effect of ferulic acid at different doses (50 mg/kg alternative day and 50 mg/kg daily) on diabetic rats and to explore the interrelationship between oxidative stress and cytokines correlates with apoptotic events in pancreatic tissue. Male Wistar rats were rendered diabetic by a single intraperitoneal injection of streptozotocin (60 mg/kg body weight). Ferulic acid was administered orally for 8 weeks. At the end of the study, all animals were sacrificed. Blood samples were collected for the biochemical estimations and pancreas was isolated for antioxidant status, histopathological, immunohistochemical, and apoptotic studies. Treatment with ferulic acid to diabetic rats significantly improved blood glucose, serum total cholesterol, triglycerides, creatinine, urea, and albumin levels toward normal. Furthermore, decrement of the elevated lipid peroxidation levels and increment of the reduced superoxide dismutase, catalase, and reduced glutathione enzyme activities in pancreatic tissues were observed in ferulic acid-treated groups. Ferulic acid-treated rats in the diabetic group showed an improved histological appearance. Our data also revealed a significant reduction in the activity of apoptosis using terminal dUTP nick end-labeling and reduced expression of TGF-β1 and IL-1β in the pancreatic β-cell of ferulic acid-treated rats. Treatment with ferulic acid daily doses produced a significant result compared to alternative dose. Collectively our results suggested that ferulic acid acts as a protective agent in diabetic rats by altering oxidative stress, expression of pro-inflammatory cytokines and apoptosis.
Souvik Roy; Satyajit Kumar Metya; Santanu Sannigrahi; Noorjaman Rahaman; Faiqa Ahmed
Related Documents :
7389818 - Release of methionine-enkephalin immunoreactivity from the rat spinal cord in vivo.
8875718 - The effects of nonsteroidal anti-inflammatory drugs on posterior spinal fusions in the ...
10964948 - Passive or active immunization with myelin basic protein promotes recovery from spinal ...
9678508 - Expression of endothelial barrier antigen immunoreactivity in blood vessels following c...
7566508 - Effects of mu opioid agonist and antagonist on neurological outcome following traumatic...
23994178 - Levofloxacin decreased chest wall mechanical inhomogeneities and airway and vascular re...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-9
Journal Detail:
Title:  Endocrine     Volume:  -     ISSN:  1559-0100     ISO Abbreviation:  Endocrine     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9434444     Medline TA:  Endocrine     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Pharmaceutical Technology, NSHM Knowledge Campus, 124 B.L. Saha Road, Kolkata, 700053, West Bengal, India,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The Association Between Cyber Victimization and Subsequent Cyber Aggression: The Moderating Effect o...
Next Document:  Excimer formation of 6-(1-pyrenyl)hexyl-11(1-pyrenyl)undecanoate within an ionic liquid and cosolven...