Document Detail


Treatment with amlodipine and atorvastatin have additive effect in improvement of arterial compliance in hypertensive hyperlipidemic patients.
MedLine Citation:
PMID:  12944027     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: This study investigates the effect of amlodipine on arterial compliance (AC), and the effect of atorvastatin on AC when given in combination with amlodipine. METHODS: Twenty-one consecutive hypertensive hyperlipidemic patients were included in this study. Patients were followed every month for 6 months (3 months of amlodipine therapy and 3 months of amlodipine and atorvastatin combination). RESULTS: During the 3 months of amlodipine monotherapy, large and small AC were improved by 26% and 38%, respectively, and the systemic vascular resistance was reduced by 10%. The addition of atorvastatin during the next 3 months improved small AC by an additional 42% and decreased the systemic vascular resistance by another 5%, but large AC and blood pressure did not change. CONCLUSIONS: Amlodipine improves large and small AC, and the beneficial effect of atorvastatin on small AC is additive to the effect achieved by amlodipine.
Authors:
Eyal Leibovitz; Maya Beniashvili; Reuven Zimlichman; Angela Freiman; Marina Shargorodsky; Dov Gavish
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  American journal of hypertension     Volume:  16     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-28     Completed Date:  2004-02-05     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  715-8     Citation Subset:  IM    
Affiliation:
Department of Medicine and the Bruner Institute of Cardiovascular Research, Wolfson Medical Center, Tel Giborim, PO Box 5, Holon, Israel 58100.
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MeSH Terms
Descriptor/Qualifier:
Aged
Amlodipine / therapeutic use*
Anticholesteremic Agents / therapeutic use*
Antihypertensive Agents / therapeutic use*
Arteries / drug effects*
Biological Markers / blood
Blood Pressure / drug effects
Calcium Channel Blockers / therapeutic use*
Cholesterol, LDL / blood,  drug effects
Diastole / drug effects
Drug Therapy, Combination
Female
Follow-Up Studies
Heart Rate / drug effects
Heptanoic Acids / therapeutic use*
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Hyperlipidemias / drug therapy*
Hypertension / drug therapy*
Male
Middle Aged
Pyrroles / therapeutic use*
Stroke Volume / drug effects
Systole / drug effects
Treatment Outcome
Vascular Resistance / drug effects
Chemical
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Antihypertensive Agents; 0/Biological Markers; 0/Calcium Channel Blockers; 0/Cholesterol, LDL; 0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrroles; 110862-48-1/atorvastatin; 88150-42-9/Amlodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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