| Treatment with amlodipine and atorvastatin have additive effect in improvement of arterial compliance in hypertensive hyperlipidemic patients. | |
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MedLine Citation:
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PMID: 12944027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: This study investigates the effect of amlodipine on arterial compliance (AC), and the effect of atorvastatin on AC when given in combination with amlodipine. METHODS: Twenty-one consecutive hypertensive hyperlipidemic patients were included in this study. Patients were followed every month for 6 months (3 months of amlodipine therapy and 3 months of amlodipine and atorvastatin combination). RESULTS: During the 3 months of amlodipine monotherapy, large and small AC were improved by 26% and 38%, respectively, and the systemic vascular resistance was reduced by 10%. The addition of atorvastatin during the next 3 months improved small AC by an additional 42% and decreased the systemic vascular resistance by another 5%, but large AC and blood pressure did not change. CONCLUSIONS: Amlodipine improves large and small AC, and the beneficial effect of atorvastatin on small AC is additive to the effect achieved by amlodipine. |
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Authors:
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Eyal Leibovitz; Maya Beniashvili; Reuven Zimlichman; Angela Freiman; Marina Shargorodsky; Dov Gavish |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article |
Journal Detail:
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Title: American journal of hypertension Volume: 16 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-08-28 Completed Date: 2004-02-05 Revised Date: 2009-02-24 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 715-8 Citation Subset: IM |
Affiliation:
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Department of Medicine and the Bruner Institute of Cardiovascular Research, Wolfson Medical Center, Tel Giborim, PO Box 5, Holon, Israel 58100. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Amlodipine / therapeutic use* Anticholesteremic Agents / therapeutic use* Antihypertensive Agents / therapeutic use* Arteries / drug effects* Biological Markers / blood Blood Pressure / drug effects Calcium Channel Blockers / therapeutic use* Cholesterol, LDL / blood, drug effects Diastole / drug effects Drug Therapy, Combination Female Follow-Up Studies Heart Rate / drug effects Heptanoic Acids / therapeutic use* Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* Hyperlipidemias / drug therapy* Hypertension / drug therapy* Male Middle Aged Pyrroles / therapeutic use* Stroke Volume / drug effects Systole / drug effects Treatment Outcome Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Antihypertensive Agents; 0/Biological Markers; 0/Calcium Channel Blockers; 0/Cholesterol, LDL; 0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrroles; 110862-48-1/atorvastatin; 88150-42-9/Amlodipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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