Document Detail


Treatment with omega-3 fatty acids but not exendin-4 improves hepatic steatosis.
MedLine Citation:
PMID:  20651599     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in the Western world. The aim of this study was to evaluate the biochemical and histological effects of omega-3 fatty acid and exendin-4 treatment on NAFLD in an animal model.
METHODS: Sixty-three 8-week-old outbred Sprague-Dawley male rats were used for this study. Three animals were used as procedure controls, and 30 rats were fed a methionine and choline deficient (MCD) diet and 30 were fed a regular chow diet. In each group of 30 animals, 10 served as controls, 10 received exendin-4, and 10 received omega-3 fatty acids. After 75 days of treatment, the animals were euthanized, the tissues and serum were harvested, and the livers were formalin-fixed for histology.
RESULTS: The MCD diet was exceptionally efficient at producing fatty livers. The MCD control animals had a liver steatosis score of 38+/-6.7 (of 50 possible); treatment with exendin-4 was not associated with a significant reduction of steatosis (44+/-5.16, P=0.07) and the omega-3 fatty acid treatment was associated with a significant decrease in the liver steatosis score (15.6+/-13.46, P<0.001) compared with both the controls and the exendin-4 groups. The omega-3 fatty acid treatment increased serum aspartate aminotransferase significantly, whereas exendin-4 had no effect.
CONCLUSION: In an animal model of NAFLD, the omega-3 fatty acid therapy was associated with significant improvement in hepatic steatosis compared with exendin-4. These data suggest that omega-3 fatty acid supplements may have a potential therapeutic role in patients with NAFLD.
Authors:
Deepti G Bulchandani; Jagdish S Nachnani; Anupama Nookala; Christina Naumovitch; Betty Herndon; Agostino Molteni; Tim Quinn; Laura M Alba
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  22     ISSN:  1473-5687     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-09     Completed Date:  2010-12-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1245-52     Citation Subset:  IM    
Affiliation:
Division of Endocrinology, University of Kansas School of Medicine, Kansas City, Missouri 64108, USA.
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MeSH Terms
Descriptor/Qualifier:
Adipokines / blood
Alkane 1-Monooxygenase / metabolism
Animals
Body Weight / drug effects
Corn Oil / pharmacology
Cytochrome P-450 CYP2E1 / metabolism
Dietary Supplements
Disease Models, Animal
Fatty Acids, Omega-3 / pharmacology*
Fatty Liver / drug therapy*,  metabolism
Fish Oils / pharmacology
Hypoglycemic Agents / pharmacology*
Insulin Resistance / physiology
Liver / drug effects*,  metabolism
Male
Peptides / pharmacology*
Rats
Rats, Sprague-Dawley
Venoms / pharmacology*
Chemical
Reg. No./Substance:
0/Adipokines; 0/Fatty Acids, Omega-3; 0/Fish Oils; 0/Hypoglycemic Agents; 0/Peptides; 0/Venoms; 141732-76-5/exenatide; 8001-30-7/Corn Oil; EC 1.14.14.1/Cytochrome P-450 CYP2E1; EC 1.14.15.3/Alkane 1-Monooxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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