Document Detail

Treatment with Lindera strychnifolia reduces blood pressure by decreasing sympathetic nerve activity in spontaneously hypertensive rats.
MedLine Citation:
PMID:  20503472     Owner:  NLM     Status:  MEDLINE    
Lindera strychnifolia (Tendai-Uyaku), a medicinal plant, has long been used for the treatment of cardiac, renal and rheumatic diseases in Japan. We investigated the effect of Lindera strychnifolia on systolic blood pressure, cardiac function, and plasma noradrenaline levels in rats. Spontaneously hypertensive rats (SHR) were given free access to water or extract solution of Lindera strychnifolia, which was extracted with a ratio of 10 g Lindera strychnifolia roots/20 ml water. Systolic blood pressure was measured by using a tail-cuf sphygmomanometer twice a week from 10 to 30 weeks of age, and compared to the age-matched Wistar Kyoto rats (WKY) as a control group. At 30 weeks of age, heart function was measured by echocardiography and blood samples were taken for detection of plasma noradrenaline levels, and rats were then sacrificed. Systolic blood pressure gradually increased from 10 to 30 weeks of age in the SHR group, while it did not change in the WKY group. In the Lindera-treated SHR group, the increase in systolic blood pressure was significantly attenuated from 21 to 30 weeks of age. Echocardiography showed a significant increase in ejection fraction in the Lindera-treated SHR group (60.4 +/- 7.8%) as compared to the SHR group (39.7 +/- 23.4%). Plasma noradrenaline levels were significantly decreased in Lindera-treated SHR group compared to the SHR group. These results suggest that Lindera strychnifolia has an anti-hypertensive effect and improves cardiac function in spontaneous hypertensive rats. These effects may be related to the decrease in plasma noradrenaline levels by Lindera strychnifolia.
Masayuki Shimomura; Hiroaki Ushikoshi; Arihiro Hattori; Ichijiro Murata; Yasushi Ohno; Takuma Aoyama; Masanori Kawasaki; Kazuhiko Nishigaki; Genzou Takemura; Takako Fujiwara; Hisayoshi Fujiwara; Shinya Minatoguchi
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of Chinese medicine     Volume:  38     ISSN:  0192-415X     ISO Abbreviation:  Am. J. Chin. Med.     Publication Date:  2010  
Date Detail:
Created Date:  2010-05-26     Completed Date:  2010-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7901431     Medline TA:  Am J Chin Med     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  561-8     Citation Subset:  IM    
Kyoto Women's University, Japan.
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MeSH Terms
Antihypertensive Agents / pharmacology*
Blood Pressure / drug effects*
Hypertension / blood,  physiopathology,  prevention & control*
Lindera / chemistry*
Norepinephrine / blood
Plant Extracts / chemistry,  pharmacology
Rats, Inbred SHR
Rats, Inbred WKY
Sympathetic Nervous System / drug effects*,  physiopathology
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Antihypertensive Agents; 0/Plant Extracts; 51-41-2/Norepinephrine

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