| Treatment with Lenalidomide does not appear to increase the risk of leukemia progression in lower risk myelodysplastic syndrome with 5q deletion. A comparative analysis by the GFM. | |
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MedLine Citation:
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PMID: 21993675 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background. Although lenalidomide is very effective in the treatment of anemia of lower risk myelodysplastic syndromes with 5q deletion (del 5q), some concerns have been raised over the fact that it could trigger progression to acute myeloid leukemia in some patients. Design and Methods. We treated 95 transfusion dependent lower risk risk myelodysplastic syndromes with del 5q by lenalidomide (10mg/d, 3 weeks every 4 weeks), of whom 6 (6.3%) progressed to acute myeloid leukemia. This cohort was compared to a historical control cohort of 99 lower risk myelodysplastic syndromes patients with del 5q who never received Lenalidomide, using a propensity score approach that allows controlling for potential confounders in non-randomized comparisons. Results. The 4-year estimated cumulative incidence of leukemia was 9% in patients treated with lenalidomide and 15.8% in controls that did not receive lenalidomide (p=0.16). Conclusions. Using a propensity score approach, we found no significant difference in acute myeloid leukemia progression and survival from diagnosis between the cohort treated with lenalidomide and the control cohort. |
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Authors:
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Lionel Ades; Fabien Lebras; Marie Sebert; Charikleia Kelaidi; Thierry Lamy; Francois Dreyfus; Virginie Eclache; Jacques Delaunay; Didier Bouscary; Sorin Visanica; Pascal Turlure; Agnes Guerci Bresler; Marie Paule Cabrol; Anne Banos; Michel Blanc; Norbert Vey; Alain Delmer; Eric Wattel; Sylvie Chevret; Pierre Fenaux |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-11 |
Journal Detail:
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Title: Haematologica Volume: - ISSN: 1592-8721 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417435 Medline TA: Haematologica Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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France; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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