Document Detail

Treatment with GnRH agonists before myomectomy and the risk of short-term myoma recurrence.
MedLine Citation:
PMID:  2115379     Owner:  NLM     Status:  MEDLINE    
Twenty-four women with symptomatic multiple uterine myomas were allocated randomly to treatment with buserelin, 1200 micrograms/day intranasally, for 3 months followed by myomectomy (n = 8) or to immediate myomectomy (n = 16). Pre-operative treatment with buserelin reduced the mean uterine volume from 432 (SD 165) to 242 (SD 82) ml (P less than 0.01) but intra-operative blood loss and postoperative morbidity were not significantly less in this group. Six months after operation, pelvic examination was normal in all the patients. However, ultrasonography with transvaginal probe demonstrated the presence of myomas of less than 1.5 cm in five women (63%) treated pre-operatively with the analogue and in two women (13%) who underwent immediate surgery (P less than 0.05). Induction of a period of hypo-oestrogenism before myomectomy seems to favour short-term recurrence of uterine myomas, limiting the efficacy of surgery.
L Fedele; P Vercellini; S Bianchi; D Brioschi; M Dorta
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  97     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-08-27     Completed Date:  1990-08-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  393-6     Citation Subset:  AIM; IM    
1st Department of Obstetrics and Gynaecology, University of Milan, Italy.
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MeSH Terms
Buserelin / therapeutic use*
Combined Modality Therapy
Leiomyoma / drug therapy*,  pathology,  surgery
Myometrium / surgery*
Neoplasm Recurrence, Local
Randomized Controlled Trials as Topic
Uterine Neoplasms / drug therapy*,  pathology,  surgery
Uterus / pathology
Reg. No./Substance:

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