| Treatment with GnRH agonists before myomectomy and the risk of short-term myoma recurrence. | |
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MedLine Citation:
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PMID: 2115379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty-four women with symptomatic multiple uterine myomas were allocated randomly to treatment with buserelin, 1200 micrograms/day intranasally, for 3 months followed by myomectomy (n = 8) or to immediate myomectomy (n = 16). Pre-operative treatment with buserelin reduced the mean uterine volume from 432 (SD 165) to 242 (SD 82) ml (P less than 0.01) but intra-operative blood loss and postoperative morbidity were not significantly less in this group. Six months after operation, pelvic examination was normal in all the patients. However, ultrasonography with transvaginal probe demonstrated the presence of myomas of less than 1.5 cm in five women (63%) treated pre-operatively with the analogue and in two women (13%) who underwent immediate surgery (P less than 0.05). Induction of a period of hypo-oestrogenism before myomectomy seems to favour short-term recurrence of uterine myomas, limiting the efficacy of surgery. |
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Authors:
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L Fedele; P Vercellini; S Bianchi; D Brioschi; M Dorta |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: British journal of obstetrics and gynaecology Volume: 97 ISSN: 0306-5456 ISO Abbreviation: Br J Obstet Gynaecol Publication Date: 1990 May |
Date Detail:
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Created Date: 1990-08-27 Completed Date: 1990-08-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7503752 Medline TA: Br J Obstet Gynaecol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 393-6 Citation Subset: AIM; IM |
Affiliation:
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1st Department of Obstetrics and Gynaecology, University of Milan, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Buserelin / therapeutic use* Combined Modality Therapy Female Humans Leiomyoma / drug therapy*, pathology, surgery Myometrium / surgery* Neoplasm Recurrence, Local Randomized Controlled Trials as Topic Uterine Neoplasms / drug therapy*, pathology, surgery Uterus / pathology |
| Chemical | |
Reg. No./Substance:
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57982-77-1/Buserelin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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