| Treatment with DNAse I fosters binding to nec PBMC of CRP. | |
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MedLine Citation:
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PMID: 19811278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CRP is an important inflammatory marker, however, CRP levels are relatively low in patients with SLE. In addition patients with SLE often display low activities and serum levels for DNase I and complement, respectively. Here we show that DNase I treatment of nec PBMC increased their binding of CRP. Consequently, reduced DNase I activity in patients with SLE may contribute to the impaired opsonisation by CRP of dead cells, exacerbating the clearance defect in SLE of apo and nec cells. |
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Authors:
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Christina Janko; Christine Schorn; Daniela Weidner; Kerstin Sarter; Ricardo Chaurio; Ahmed Sheriff; Georg Schett; Luis E Munoz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Autoimmunity Volume: 42 ISSN: 1607-842X ISO Abbreviation: Autoimmunity Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-10-08 Completed Date: 2009-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8900070 Medline TA: Autoimmunity Country: England |
Other Details:
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Languages: eng Pagination: 286-8 Citation Subset: IM |
Affiliation:
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Department for Internal Medicine 3, Institute for Clinical Immunology, Friedrich-Alexander University of Erlangen-N??rnberg, Erlangen, Germany. christina.janko@uk-erlangen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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C-Reactive Protein
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metabolism* Cells, Cultured Deoxyribonuclease I / immunology, metabolism* Flow Cytometry Humans Leukocytes, Mononuclear / immunology, metabolism*, pathology* Necrosis Phagocytosis / immunology |
| Chemical | |
Reg. No./Substance:
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9007-41-4/C-Reactive Protein; EC 3.1.21.1/Deoxyribonuclease I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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