Document Detail


Treatment with C1 inhibitor concentrate in abdominal pain attacks of patients with hereditary angioedema.
MedLine Citation:
PMID:  16271103     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Abdominal edema attacks in patients with hereditary angioedema are often extremely painful, associated with vomiting and diarrhea, and have a high potential for causing recurrent disability of the patient. STUDY DESIGN AND METHODS: Intraindividual comparison of retrospective data in 75 hereditary angioedema patients comprising 4,834 abdominal attacks treated with C1 inhibitor concentrate versus 17,444 untreated abdominal attacks. RESULTS: The mean duration of abdominal attacks was 92.0 hours (SD, 40.8 hr) when untreated compared to 39.9 hours (SD, 30.0 hr) when treated. Patients reported a mean maximal pain score of 8.6 (SD, 1.7; range, 1-10) for untreated attacks compared to 4.5 (SD, 2.9) when treated. Vomiting occurred in 83.3 percent of untreated attacks and in 6.0 percent of treated attacks, respectively. Diarrhea was reported in 41.8 percent of untreated attacks and in 11.0 percent of treated attacks, whereas cardiovascular collapse due to hypovolemia was observed in 3.5 percent of untreated attacks versus 0.1 percent in treated attacks. Mean time to relief of symptoms was 53.5 minutes when treated early compared to 114 minutes when treatment was delayed. No drug-related adverse or serious adverse events were observed as far as the injections were performed correctly. CONCLUSION: C1 inhibitor concentrate is highly effective and safe in treating abdominal attacks in patients suffering from hereditary angioedema.
Authors:
Konrad Bork; Gabriele Meng; Petra Staubach; Jochen Hardt
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Transfusion     Volume:  45     ISSN:  0041-1132     ISO Abbreviation:  Transfusion     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-07     Completed Date:  2005-12-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1774-84     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Johannes Gutenberg University, Mainz, Germany. bork@hautklinik.klinik.uni-mainz.de
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MeSH Terms
Descriptor/Qualifier:
Abdominal Pain / drug therapy*,  etiology*,  physiopathology
Adolescent
Adult
Angioedema / complications*,  genetics*
Bed Rest
Child
Child, Preschool
Complement C1 Inactivator Proteins / administration & dosage,  therapeutic use*
Diarrhea / drug therapy,  etiology
Dose-Response Relationship, Drug
Drug Administration Schedule
Humans
Hypovolemia / complications
Infant
Injections
Patient Satisfaction
Retrospective Studies
Serpins / administration & dosage,  therapeutic use*
Time Factors
Treatment Outcome
Unconsciousness / drug therapy,  etiology
Vomiting / drug therapy,  etiology
Chemical
Reg. No./Substance:
0/Complement C1 Inactivator Proteins; 0/SERPING1 protein, human; 0/Serpins

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