Document Detail


Treatment of vitiligo with oral methoxsalen and UVA.
MedLine Citation:
PMID:  6531291     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
139 patients with vitiligo of long duration were treated with oral 8-MOP and UVA. 22 patients had focal and 117 generalized vitiligo. 27 had vitiligo on the skin of their face and/or neck and 58 on their hands and/or feet. Vitiligo of the face and/or neck responded very well to the treatment, 14 of 27 (52%) repigmenting completely, while the treatment results of hands and/or feet were poor (complete repigmentation in 2 of 58 cases (3%). In cases with focal vitiligo total repigmentation was observed much more frequently (in 11 of 22 cases) than in cases with generalized vitiligo (in 23 of 117 cases). Acute toxic effects were frequent, erythema in 55 cases (40%), nausea in 46 cases (33%), pruritus in 16 cases (12%) and headache in 8 cases (6%). Long-term adverse effects such as hypertrichosis and actinic keratoses occurred in 3 cases each. 6 patients (4%) had elevated transminases at some stage of the treatment. This did not cause withdrawal from treatment in any of the cases.
Authors:
A Lassus; K Halme; A Eskelinen; A Ranki; P Puska; O Salo
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Photo-dermatology     Volume:  1     ISSN:  0108-9684     ISO Abbreviation:  Photodermatol     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1985-04-26     Completed Date:  1985-04-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8407997     Medline TA:  Photodermatol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  170-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Female
Humans
Male
Methoxsalen / administration & dosage
PUVA Therapy* / adverse effects
Photochemotherapy* / adverse effects
Vitiligo / drug therapy*
Chemical
Reg. No./Substance:
298-81-7/Methoxsalen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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