Document Detail

Treatment of ventilation-induced lung injury with exogenous surfactant.
MedLine Citation:
PMID:  11355126     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: It has been demonstrated that pulmonary surfactant plays a role in the pathophysiology of ventilation-induced lung injury (VILI). Therefore, we investigated whether exogenous surfactant might restore lung function and lung mechanics in an established model of VILI. DESIGN: Prospective, randomized, animal study. SETTING: Experimental laboratory of a university. SUBJECTS: Twenty-four adult male Sprague-Dawley rats. INTERVENTIONS: First, a group of six animals were killed immediately after induction of anesthesia and used as healthy controls. Then, in 18 rats, VILI was induced by increasing peak inspiratory pressure (PIP) to 45 cmH2O without positive end-expiratory pressure (PEEP) for 20 min. Thereafter, animals were randomly divided into three groups of six animals each: one group was killed immediately after VILI and served as VILI-control. In the other two groups, ventilator settings were changed to a PIP of 30 cmH2O and a PEEP of 10 cmH2O, and a respiratory rate of 40 bpm. One group received a bolus of surfactant and the other group received no treatment. MEASUREMENTS AND RESULTS: Blood gas tension and arterial blood pressures were recorded every 30 min for 2 h. After the study period, a pressure-volume curve was recorded. Then, a broncho-alveolar lavage (BAL) was performed to determine protein content, minimal surface tension, and surfactant composition in the BAL fluid. Oxygenation, lung mechanics, surfactant function and composition were significantly improved in the surfactant-treated group compared to the ventilated and non-ventilated control groups. CONCLUSION: We conclude that exogenous surfactant can be used to treat VILI.
G F Vazquez de Anda; R A Lachmann; D Gommers; S J Verbrugge; J Haitsma; B Lachmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Intensive care medicine     Volume:  27     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-05-17     Completed Date:  2001-10-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  559-65     Citation Subset:  IM    
Department of Anesthesiology, (Room Ee 2393), Erasmus University Rotterdam, P.O. Box 1738, 3000 Rotterdam, The Netherlands.
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MeSH Terms
Blood Gas Analysis
Bronchoalveolar Lavage Fluid / chemistry,  cytology
Disease Models, Animal*
Drug Evaluation, Preclinical
Lung Volume Measurements
Positive-Pressure Respiration / adverse effects*,  methods
Prospective Studies
Pulmonary Gas Exchange / drug effects
Pulmonary Surfactants / pharmacology,  therapeutic use*
Random Allocation
Rats, Sprague-Dawley
Respiration, Artificial / adverse effects*
Respiratory Distress Syndrome, Adult / blood,  drug therapy*,  etiology*,  physiopathology
Respiratory Mechanics / drug effects
Reg. No./Substance:
0/Pulmonary Surfactants

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