| Treatment of uterine fibroids with agonist analogs of gonadotropin-releasing hormone. | |
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MedLine Citation:
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PMID: 3277869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Agonist analogs of GnRH were used to effect a "medical castration" in 14 patients with uterine fibroids, presenting with either an enlarged uterus, recurrent menometrorrhagia, and/or infertility. This study confirms prior reports of a reduction in uterine size and cessation of menometrorrhagia in patients with fibroids following treatment with GnRHa. Of interest, however, was the successful use of GnRHa as either the sole treatment for uterine fibroid-associated infertility, or as a preoperative adjunct in infertility patients scheduled for myomectomy. Three of the five infertility patients in this study achieved intrauterine pregnancies. Further study of the role of GnRHa treatment in infertility patients with uterine fibroids appears warranted. |
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Authors:
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B Kessel; J Liu; J Mortola; S Berga; S S Yen |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Fertility and sterility Volume: 49 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 1988 Mar |
Date Detail:
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Created Date: 1988-03-29 Completed Date: 1988-03-29 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 538-41 Citation Subset: IM |
Affiliation:
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Department of Reproductive Medicine, School of Medicine, University of California, San Diego, La Jolla 92093. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Gonadotropin-Releasing Hormone / analogs & derivatives*, therapeutic use Humans Leiomyoma / drug therapy* Triptorelin* / analogs & derivatives* Uterine Neoplasms / drug therapy* |
| Grant Support | |
ID/Acronym/Agency:
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HD-00653/HD/NICHD NIH HHS; HD-12303/HD/NICHD NIH HHS; RR-00827/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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33515-09-2/Gonadotropin-Releasing Hormone; 57773-63-4/Triptorelin; 57773-65-6/Tryptal; 76712-82-8/histrelin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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