Document Detail

Treatment of therapy-resistant Alopecia areata with fumaric acid esters.
MedLine Citation:
PMID:  16899425     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Alopecia areata is a cosmetically very disfiguring clinical picture and can be a great emotional burden to the patient, especially when persisting for a longer period of time.
PATIENTS AND METHODS: 10 patients with an alopecia resistant to therapy were treated within the bounds of an open, non-placebo controlled pilot study with fumaric acid esters (FAE's, Fumaderm) for a period of six months and a maximum dose of 120 mg dimethylfumarate per day. The shortest space of time between persistent Alopecia areata and the start of the therapy with FAE was between six months and 17 years.
RESULTS: Six patients took benefit from the six months therapy with FAE. In three of them very good results could be observed, presenting an almost entire remission, one patient showed a good success with a focal remission. With two patients a mediocre to moderate outcome was observed with growth of partly diffuse spread or very thin hair. Four patients took no benefit from the FAE therapy at all.
CONCLUSIONS: FAE can be useful in the treatment of therapy-resistant Alopecia areata. This therapy approach should be validated in a multi-centre study.
I Venten; N Hess; A Hirschmüller; P Altmeyer; N Brockmeyer
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  European journal of medical research     Volume:  11     ISSN:  0949-2321     ISO Abbreviation:  Eur. J. Med. Res.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-08-10     Completed Date:  2006-10-03     Revised Date:  2013-04-01    
Medline Journal Info:
Nlm Unique ID:  9517857     Medline TA:  Eur J Med Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  300-5     Citation Subset:  IM    
Department of Dermatology, Ruhr-University Bochum, Gudrunstrasse 56, D-44791 Bochum, Germany.
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MeSH Terms
Administration, Topical
Alopecia Areata / drug therapy*,  immunology
CD4-CD8 Ratio
Dermatologic Agents / administration & dosage,  therapeutic use*
Dose-Response Relationship, Drug
Follow-Up Studies
Fumarates / administration & dosage,  therapeutic use*
Pilot Projects
Treatment Outcome
Reg. No./Substance:
0/Dermatologic Agents; 0/Fumarates; FO2303MNI2/dimethyl fumarate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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