| Treatment of symptomatic lower extremity acute deep venous thrombosis: role of mechanical thrombectomy. | |
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MedLine Citation:
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PMID: 17976330 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Systemic anticoagulation with heparin or its unfractionated derivatives followed by warfarin therapy has been the mainstay of treatment in patients with lower extremity deep venous thrombosis (DVT). Although heparin is an effective treatment modality in preventing thrombus propagation, it provides minimal therapeutic effect in dissolving preexisting venous thrombus. The clinical consequence of DVT, owing in part to loss of venous endothelial and valvular function, is postphlebitic syndrome or chronic venous insufficiency. Current advances in endovascular therapy have resulted in various endovascular thrombectomy systems that can effectively remove a large venous thrombus burden, which may represent a potential advantage of preserving venous valvular function and thereby reduce the likelihood of postphlebitic syndrome. In this article, we review a variety of surgical and interventional methods in venous thrombus removal. Current treatment modalities using mechanical thrombectomy devices and pharmacomechancial thrombectomy strategy are also discussed. |
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Authors:
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Andre Biuckians; George H Meier |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Vascular Volume: 15 ISSN: 1708-5381 ISO Abbreviation: Vascular Publication Date: 2007 Sep-Oct |
Date Detail:
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Created Date: 2007-11-02 Completed Date: 2008-05-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101196722 Medline TA: Vascular Country: Canada |
Other Details:
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Languages: eng Pagination: 297-303 Citation Subset: IM |
Affiliation:
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Division of Vascular Surgery, Eastern Virginia Medical School, Norfolk, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Humans Leg / blood supply* Surgical Procedures, Minimally Invasive / methods Thrombectomy / adverse effects, methods* Thrombolytic Therapy / methods Venous Thrombosis / drug therapy, surgery* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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