Document Detail

Treatment of symptomatic lower extremity acute deep venous thrombosis: role of mechanical thrombectomy.
MedLine Citation:
PMID:  17976330     Owner:  NLM     Status:  MEDLINE    
Systemic anticoagulation with heparin or its unfractionated derivatives followed by warfarin therapy has been the mainstay of treatment in patients with lower extremity deep venous thrombosis (DVT). Although heparin is an effective treatment modality in preventing thrombus propagation, it provides minimal therapeutic effect in dissolving preexisting venous thrombus. The clinical consequence of DVT, owing in part to loss of venous endothelial and valvular function, is postphlebitic syndrome or chronic venous insufficiency. Current advances in endovascular therapy have resulted in various endovascular thrombectomy systems that can effectively remove a large venous thrombus burden, which may represent a potential advantage of preserving venous valvular function and thereby reduce the likelihood of postphlebitic syndrome. In this article, we review a variety of surgical and interventional methods in venous thrombus removal. Current treatment modalities using mechanical thrombectomy devices and pharmacomechancial thrombectomy strategy are also discussed.
Andre Biuckians; George H Meier
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Vascular     Volume:  15     ISSN:  1708-5381     ISO Abbreviation:  Vascular     Publication Date:    2007 Sep-Oct
Date Detail:
Created Date:  2007-11-02     Completed Date:  2008-05-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101196722     Medline TA:  Vascular     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  297-303     Citation Subset:  IM    
Division of Vascular Surgery, Eastern Virginia Medical School, Norfolk, USA.
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MeSH Terms
Acute Disease
Leg / blood supply*
Surgical Procedures, Minimally Invasive / methods
Thrombectomy / adverse effects,  methods*
Thrombolytic Therapy / methods
Venous Thrombosis / drug therapy,  surgery*

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