| Treatment of suture line bleeding with a novel synthetic surgical sealant in a canine iliac PTFE graft model. | |
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MedLine Citation:
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PMID: 11319746 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CoSeal mark surgical sealant (CoSeal) was evaluated for inhibiting suture line bleeding using a canine iliac PTFE graft model. Both iliac arteries of 12 heparinized canines were grafted with PTFE. CoSeal was applied to the suture lines of one graft in each animal. The contra-lateral graft served as a control and bleeding was controlled with gauze and pressure (tamponade). The cross-clamps were removed 30 s following application of CoSeal. Times to hemostasis and volume of blood loss at each graft site were determined. Compared to tamponade control, CoSeal significantly reduced the time to hemostasis (average of 5 min vs. greater than 15 min, p < 0.05) and blood loss (19 g vs. 284 g, p < 0.05). Small amounts of CoSeal were visible grossly or histologically at day 7. Histology showed moderate to marked inflammation in CoSeal sites and moderate inflammation in control sites at day 7. At 30 and 60 days, no CoSeal was visible grossly or histologically. Histology showed moderate inflammation in both CoSeal treated sites and in control sites at day 30 and mild to moderate inflammation in both CoSeal and control sites at day 60. CoSeal significantly reduced the time to hemostasis and blood loss in comparison to tamponade. |
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Authors:
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A Hill; T D Estridge; M Maroney; E Monnet; B Egbert; G Cruise; G T Coker |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of biomedical materials research Volume: 58 ISSN: 0021-9304 ISO Abbreviation: J. Biomed. Mater. Res. Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-04-25 Completed Date: 2001-07-26 Revised Date: 2006-09-14 |
Medline Journal Info:
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Nlm Unique ID: 0112726 Medline TA: J Biomed Mater Res Country: United States |
Other Details:
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Languages: eng Pagination: 308-12 Citation Subset: IM |
Copyright Information:
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Copyright 2001 John Wiley & Sons, Inc. |
Affiliation:
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Department of Cardiothoracic Surgery, University of California, San Francisco, California, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biocompatible Materials Blood Loss, Surgical / prevention & control Blood Vessel Prosthesis Implantation / adverse effects, methods* Dogs Hemostasis, Surgical / methods* Materials Testing Polyethylene Glycols Polytetrafluoroethylene Suture Techniques* |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/CoSeal; 0/Polyethylene Glycols; 9002-84-0/Polytetrafluoroethylene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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