Document Detail

Treatment of supine hypertension in autonomic failure with gastrostomy feeding at night.
MedLine Citation:
PMID:  18653386     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Supine hypertension and post-prandial hypotension are associated with chronic autonomic failure, and may prove resistant to treatment. We determined if the hypotensive effects of food could be utilised to reduce supine hypertension in pure autonomic failure (PAF). METHODS: A subject with long-standing PAF, documented supine hypertension and post-prandial hypotension had a gastrostomy tube placed for dysphagia. We compared 24-hour ambulatory blood pressure recordings before and after nocturnal gastrostomy feeding. RESULTS: Gastrostomy feeding was associated with resolution of supine hypertension and normalization of circadian BP rhythm. CONCLUSIONS: Gastrostomy feeding at night may help reduce supine hypertension in autonomic failure.
Tim M Young; Christopher J Mathias
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-24
Journal Detail:
Title:  Autonomic neuroscience : basic & clinical     Volume:  143     ISSN:  1872-7484     ISO Abbreviation:  Auton Neurosci     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-25     Completed Date:  2009-02-03     Revised Date:  2009-08-12    
Medline Journal Info:
Nlm Unique ID:  100909359     Medline TA:  Auton Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  77-8     Citation Subset:  IM    
Neurovascular Medicine Unit, Faculty of Medicine, Imperial College London at St. Mary's Hospital, United Kingdom.
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MeSH Terms
Enteral Nutrition / methods*
Gastrostomy / methods*
Hypertension / etiology,  physiopathology,  therapy*
Pure Autonomic Failure / complications*
Supine Position
Treatment Outcome

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