Document Detail

Treatment strategies for acute pulmonary embolism.
MedLine Citation:
PMID:  19405790     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Acute pulmonary embolism (PE) is a life-threatening condition that has been treated with anticoagulation for almost 50 years. OBJECTIVES: To review the current treatment options for PE and discuss recently published new features. METHODS: We reviewed literature involving the treatment strategies for venous thromboembolism (VTE) and in particular pulmonary embolism. Specific attention was drawn towards the evidence of the present treatment and of drugs being studied in Phase III trials. RESULTS/CONCLUSIONS: Treatment of acute PE consists of parenteral administration of heparin, low-molecular-weight heparin or fondaparinux overlapped and followed by oral vitamin K antagonists for a minimum of 3 months. Contemporary features include the emergence of new anticoagulant drugs such as oral synthetic inhibitors of thrombin or factor Xa. The duration of anticoagulation for unprovoked VTE remains highly debated.
Marc Blondon; Henri Bounameaux; Marc Righini
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert opinion on pharmacotherapy     Volume:  10     ISSN:  1744-7666     ISO Abbreviation:  Expert Opin Pharmacother     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-01     Completed Date:  2009-07-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100897346     Medline TA:  Expert Opin Pharmacother     Country:  England    
Other Details:
Languages:  eng     Pagination:  1159-71     Citation Subset:  IM    
Division of General Internal Medicine, Department of Internal Medicine, Geneva University Hospital and Faculty of Medicine, 24 rue Micheli-du-Crest, CH-1211 Geneva 14, Switzerland.
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MeSH Terms
Acute Disease
Pregnancy Complications, Cardiovascular / drug therapy,  surgery,  therapy
Pulmonary Embolism / complications,  drug therapy,  surgery,  therapy*
Thrombolytic Therapy
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