| Treatment of sperm with platelet-activating factor does not improve intrauterine insemination outcome in unselected cases of mild male factor infertility: a prospective double-blind randomized crossover study. | |
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MedLine Citation:
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PMID: 19716589 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To evaluate the effect of sperm treatment with exogenous platelet-activating factor (PAF) on intrauterine insemination (IUI) clinical pregnancy rate in cases of mild male factor infertility. PAF is a phospholipid mediator, which is present in human sperm. METHODS: The study was performed in the Assisted Reproduction Unit of the 2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, Athens, Greece, and included 92 couples who presented with mild male factor infertility-all candidates for IUI. A maximum of 4 IUI cycles per couple with or without exogenous PAF treatment were performed and the main outcome measure was the clinical pregnancy rate (pregnancies confirmed by ultrasonography per 100 cycles). RESULTS: The overall clinical pregnancy rate after a maximum of 4 IUI cycles was comparable in cases with and without sperm treatment with PAF (12.24% vs 11.11%). Addition or exclusion of PAF sperm treatment in the same patients did not significantly alter the outcome. CONCLUSIONS: The generalized use of exogenous PAF for the preparation of sperm in unselected cases of mild male infertility does not improve the clinical outcome of IUI. |
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Authors:
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Stavroula Baka; Odysseas Grigoriou; Dimitris Hassiakos; Socrates Konidaris; Konstantinos Papadias; Evangelos Makrakis |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2009-08-29 |
Journal Detail:
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Title: Urology Volume: 74 ISSN: 1527-9995 ISO Abbreviation: Urology Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-03 Completed Date: 2009-11-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0366151 Medline TA: Urology Country: United States |
Other Details:
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Languages: eng Pagination: 1025-8 Citation Subset: IM |
Affiliation:
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Assisted Reproduction Unit, 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, Athens, Greece. ivf@aretaieio.uoa.gr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cross-Over Studies Double-Blind Method Female Humans Infertility, Male* Insemination, Artificial* Male Platelet Activating Factor / pharmacology* Pregnancy / statistics & numerical data Prospective Studies Severity of Illness Index Spermatozoa / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Platelet Activating Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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