Document Detail


Treatment of smell loss with systemic methylprednisolone.
MedLine Citation:
PMID:  22888485     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND AIM: Olfactory dysfunction is a common complaint in a large number of people. As the aetiologies of olfactory dysfunction vary greatly so do the treatment approaches. The aim of this retrospective study was to evaluate treatment with systemic corticosteroids, particularly focusing on its effectiveness on the different olfactory dysfunction aetiologies. Although a prospective randomized control trail is preferred for such an investigation, using the current approach, we were able to test a very large patient population.
MATERIAL AND METHODS: A total of 425 patients with olfactory dysfunction were treated with systemic corticosteroids for 14 days. Olfactory performance was measured using the `Sniffin` Sticks` battery before and after the treatment.
RESULTS: The treatment with systemic corticosteroids significantly increased the performance on the TDI score and on each of the three subtests; threshold, discrimination and identification. In 26.6% of the patients improvement of more than six points of the TDI score was observed. The treatment proved to be more effective in patients with sinunasal olfactory dysfunction, where this percentage increased to 36.7, compared to other aetiologies. In addition, the increase in olfactory function was negatively correlated with the TDI score before the treatment.
CONCLUSION: This study confirms the effectiveness of systemic corticosteroids on olfactory dysfunction in a large patient population. Specifically, the results show that treatment is: (a) more effective in patients with sinunasal than in patients with idiopathic olfactory dysfunction, (b) most effective in patients with sinunasal disease with nasal polyps, and (c), at best, effective in half of the patients. The current study may provide help in counselling patients.
Authors:
V A Schriever; C Merkonidis; N Gupta; C Hummel; T Hummel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Rhinology     Volume:  50     ISSN:  0300-0729     ISO Abbreviation:  Rhinology     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-13     Completed Date:  2013-02-12     Revised Date:  2013-06-15    
Medline Journal Info:
Nlm Unique ID:  0347242     Medline TA:  Rhinology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  284-9     Citation Subset:  IM    
Affiliation:
Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Drug Administration Schedule
Female
Glucocorticoids / administration & dosage*
Humans
Male
Methylprednisolone / administration & dosage*
Middle Aged
Olfaction Disorders / drug therapy*,  etiology,  physiopathology
Olfactory Perception / physiology
Retrospective Studies
Sensory Thresholds / physiology
Treatment Outcome
Young Adult
Chemical
Reg. No./Substance:
0/Glucocorticoids; 83-43-2/Methylprednisolone

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