Document Detail

Treatment site reactions to Zyderm Collagen Implantation.
MedLine Citation:
PMID:  6221039     Owner:  NLM     Status:  MEDLINE    
Two cases of treatment site granulomatous reaction to Zyderm Collagen Implant that occurred in spite of a negative skin test are reported. A delayed hypersensitivity reaction to ZCI is suggested by the clinical time course and the histologic findings of hypersensitivity granulomas. Humoral immunity is also implicated in the reaction since elevated anti-Zyderm serum antibodies and plasma cell infiltrates are present. Resolution of the clinical signs and symptoms occurred over several months with no treatment. The physician using ZCI should be aware of this rare adverse reaction.
N A Swanson; J G Stoner; R J Siegle; A R Solomon
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of dermatologic surgery and oncology     Volume:  9     ISSN:  0148-0812     ISO Abbreviation:  J Dermatol Surg Oncol     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-06-10     Completed Date:  1983-06-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7707501     Medline TA:  J Dermatol Surg Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  377-80     Citation Subset:  IM    
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MeSH Terms
Acne Vulgaris / drug therapy
Antibodies / analysis
Cicatrix / drug therapy
Collagen / administration & dosage,  adverse effects*,  immunology
Drug Implants
Granuloma / chemically induced,  pathology
Granuloma, Giant Cell / chemically induced,  pathology
Hypersensitivity, Delayed / chemically induced*
Reg. No./Substance:
0/Antibodies; 0/Drug Implants; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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