Document Detail

Treatment of shock in a canine model of pulmonary embolism.
MedLine Citation:
PMID:  6497165     Owner:  NLM     Status:  MEDLINE    
Despite the high mortality (greater than 30%) associated with hypotension complicating pulmonary embolism, previous studies have not systematically investigated how best to treat shock resulting from pulmonary embolism. In 24 dogs, we measured relevant hemodynamic parameters before and after shock was produced by intravenously injected autologous blood clots. When systemic blood pressure fell to 70 mmHg, dogs were randomly divided into groups and treated blindly for 1 h. All control dogs and all dogs treated with volume and isoproterenol died. In contrast, all dogs treated with noradrenaline were resuscitated and remained hemodynamically stable for 1 h. This effect of noradrenaline was significant (p less than 0.01, Fisher's exact test). Noradrenaline improved right ventricular performance by increasing blood pressure and improving right ventricular perfusion and/or by a direct increase in contractility. We conclude that in a canine model of pulmonary embolism and shock, noradrenaline may be the drug of choice for acute resuscitation.
W D Molloy; K Y Lee; L Girling; U Schick; R M Prewitt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  130     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1984-11-30     Completed Date:  1984-11-30     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  870-4     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure / drug effects
Cardiac Output / drug effects
Isoproterenol / therapeutic use*
Myocardial Contraction / drug effects
Norepinephrine / therapeutic use*
Plasma Substitutes / therapeutic use*
Pulmonary Embolism / complications*
Random Allocation
Shock / drug therapy,  etiology,  therapy*
Vascular Resistance / drug effects
Reg. No./Substance:
0/Plasma Substitutes; 51-41-2/Norepinephrine; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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