Document Detail


Treatment of severe hyponatremia: conventional and novel aspects.
MedLine Citation:
PMID:  11251026     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hyponatremia is a frequent electrolyte disorder. A hyponatremia is called acute severe (<115 mM) when the duration has been <36 to 48 h. Such patients often have advanced symptoms as a result of brain edema. Acute severe hyponatremia is a medical emergency. It should be corrected rapidly to approximately 130 mM to prevent permanent brain damage. In contrast, in chronic severe hyponatremia (>4 to 6 d), there is no brain edema and symptoms are usually mild. In such patients, a number of authors have recommended a correction rate <0.5 mM/h to approximately 130 mM to minimize the risk of cerebral myelinolysis. Sometimes it is not possible to diagnose whether a severe hyponatremia is acute or chronic. In such cases, an initial imaging procedure is helpful in deciding whether rapid or slow correction should be prescribed. The modalities of treatment of severe hyponatremia have so far consisted of infusions of hypertonic saline plus fluid restriction. In the near future, vasopressin antagonists will become available. Preliminary experience has already demonstrated their efficiency of inducing a sustained water diuresis and a correction of hyponatremia.
Authors:
P Gross; D Reimann; J Henschkowski; M Damian
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of the American Society of Nephrology : JASN     Volume:  12 Suppl 17     ISSN:  1046-6673     ISO Abbreviation:  J. Am. Soc. Nephrol.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-19     Completed Date:  2001-05-10     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9013836     Medline TA:  J Am Soc Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S10-4     Citation Subset:  IM    
Affiliation:
Department of Medicine, Universitätsklinikum Carl Gustav Carus, Dresden, Germany. peter.gross@mailbox.tu-dresden.de
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Brain Edema / etiology
Humans
Hyponatremia / complications,  drug therapy,  therapy*
Myelinolysis, Central Pontine / etiology
Nephrology / trends
Receptors, Vasopressin / antagonists & inhibitors
Chemical
Reg. No./Substance:
0/Receptors, Vasopressin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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