Document Detail

Treatment of severe fetal chylothorax associated with pronounced hydrops with intrapleural injection of OK-432.
MedLine Citation:
PMID:  12528165     Owner:  NLM     Status:  MEDLINE    
We describe a case of a 25-week fetus with severe bilateral pleural effusion, marked ascites, skin edema, an anterior thick (hydropic) placenta and polyhydramnios in which the most probable diagnosis was congenital chylothorax. Treatment with a pleuroamniotic shunt was planned, however the location of the fetus just below the anterior placenta made the placement of the shunt too dangerous. We therefore decided to use intrapleural injection of OK-432. From week 29, the lungs looked normal, the pleural effusion had resolved and the thoracic circumference was within normal limits. The severe ascites persisted throughout the pregnancy and a total volume of 3680 mL was removed on several occasions. A Cesarean section was performed at 38 weeks and a normal male was delivered. Continuous positive airway pressure was needed on the first 4 days but after a week the situation was stable. On day 8, an X-ray showed normally developed lungs. OK-432 appears to have prevented pulmonary hypoplasia in our patient.
C Jorgensen; V Brocks; J Bang; F S Jorgensen; L Rønsbro
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  21     ISSN:  0960-7692     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-01-15     Completed Date:  2003-05-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  66-9     Citation Subset:  IM    
Copyright Information:
Copyright 2003 ISUOG. Published by John Wiley & Sons, Ltd.
Department of Fetal and Maternal Ultrasound, The Juliane Marie Centre for Children, Women and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
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MeSH Terms
Chylothorax / complications,  drug therapy*,  ultrasonography
Gestational Age
Hydrops Fetalis / complications*,  ultrasonography
Picibanil / administration & dosage*
Reg. No./Substance:

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