Document Detail

Treatment of severe acute respiratory distress syndrome: a final report on a phase I study.
MedLine Citation:
PMID:  11308009     Owner:  NLM     Status:  MEDLINE    
Adult respiratory distress syndrome (ARDS) has a high mortality. Its only effective treatment is respiratory therapy. If this fails mortality is probably 100 per cent. No other treatment for ARDS has proved effective including "magic bullets." Twenty patients suffering from ARDS secondary to trauma and/or sepsis failed to respond to treatment with mechanical ventilation and positive end-expiratory pressure. On the assumption that disseminated intravascular coagulation initiates ARDS by occluding the pulmonary microcirculation with microclots, the patients were treated with plasminogen activators. The patients responded with significant improvement in partial pressure of oxygen in arterial blood. No bleeding occurred and clotting parameters remained normal. We conclude that ARDS can be safely treated with plasminogen activator.
R M Hardaway; H Harke; A H Tyroch; C H Williams; Y Vazquez; G F Krause
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Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase I; Journal Article; Multicenter Study    
Journal Detail:
Title:  The American surgeon     Volume:  67     ISSN:  0003-1348     ISO Abbreviation:  Am Surg     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-18     Completed Date:  2001-05-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370522     Medline TA:  Am Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  377-82     Citation Subset:  IM    
Department of Surgery, Texas Tech University School of Medicine, El Paso 79902, USA.
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MeSH Terms
Aged, 80 and over
Blood Gas Analysis
Child, Preschool
Combined Modality Therapy
Middle Aged
Multiple Trauma / complications
Oxygen / blood
Plasminogen Activators / pharmacology,  therapeutic use*
Respiration, Artificial
Respiratory Distress Syndrome, Adult / complications,  drug therapy*,  metabolism,  mortality
Sepsis / complications
Severity of Illness Index
Streptokinase / pharmacology,  therapeutic use*
Survival Analysis
Treatment Outcome
Urokinase-Type Plasminogen Activator / pharmacology,  therapeutic use*
Reg. No./Substance:
7782-44-7/Oxygen; EC 3.4.-/Streptokinase; EC 3.4.21.-/Plasminogen Activators; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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