Document Detail


Treatment of second degree facial burns with allografts--preliminary results.
MedLine Citation:
PMID:  15993304     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Facial burns are very common and have significant clinical impact. However, the treatment regimen for superficial to deep facial burns is not well defined. The purpose of this study was to investigate the effects of cadaver skin grafting in deep partial thickness facial burns in comparison to standard care. In a prospective open study design severely injured patients with superficial and deep partial thickness burns were randomized into the group receiving open treatment with silversulfadiazine (standard n=5) or into the group receiving early superficial debridement followed by coverage with glycerolized cadaver skin (n=5). The outcome measures were time and quality of wound healing, and incidence of hypertrophic scarring at 3 and 6 months post burn. There were no significant differences in demographics between groups. In the group treated with the allogenic material time to reepithelialization was 10.5 days, while it was 12.4 days in the silversulfadiazine group (p<0.05). Scar quality was found to be significantly improved in the allogenic treatment group. Three and 6 months postburn there were no patients with significant hypertrophic scarring in the allogenic group while there were two patients who developed hypertrophic scars in the silversulfadiazine group (p<0.05). In this study, we demonstrated that glyzerolized cadaver allograft skin represents a superior biological dressing for shallow and deep partial thickness facial burns. This is in concordance with other reports on scalds. It would be worthwhile to perform more clinical studies with a larger number of patients to further evaluate the effect and function of allogenic skin for facial burns.
Authors:
Raymund E Horch; Marc G Jeschke; Gerald Spilker; David N Herndon; Jürgen Kopp
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2005-03-21
Journal Detail:
Title:  Burns : journal of the International Society for Burn Injuries     Volume:  31     ISSN:  0305-4179     ISO Abbreviation:  Burns     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-04     Completed Date:  2005-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913178     Medline TA:  Burns     Country:  England    
Other Details:
Languages:  eng     Pagination:  597-602     Citation Subset:  IM    
Affiliation:
Department of Plastic and Hand Surgery, Medical School, Friedrich-Alexander-University, Erlangen-Nürnberg 12, 91054 Erlangen, Freiburg, Germany. horchrd@chir.imed.uni-erlangen.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anti-Infective Agents, Local / therapeutic use
Burns / surgery*
Cicatrix / prevention & control
Debridement
Facial Injuries / surgery*
Female
Humans
Male
Middle Aged
Prospective Studies
Silver Sulfadiazine / therapeutic use
Skin Transplantation / methods*
Transplantation, Homologous
Treatment Outcome
Wound Healing
Chemical
Reg. No./Substance:
0/Anti-Infective Agents, Local; 22199-08-2/Silver Sulfadiazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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