Document Detail

Treatment of rheumatoid joint inflammation with intrasynovial triamcinolone hexacetonide.
MedLine Citation:
PMID:  8523335     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the effectiveness of intrasynovial triamcinolone hexacetonide coupled with joint rest (3 weeks upper extremity; 6 weeks lower extremity) in the treatment of joint and tendon sheath inflammation in patients with seropositive rheumatoid arthritis (RA). METHODS: The medical records of 169 patients with seropositive RA treated by a single rheumatologist for at least one year between 1974 and 1992 were abstracted. RESULTS: Nine hundred fifty-six injections were given to 140 patients; approximately 75% of injected synovial structures remained in remission during a mean followup 7 years; 218 injections were given into previously treated structures. The injection rate was about 2 per patient in the first year, half of which were given at the time of the first visit. The rate then approximated 0.6 injections per patient-year for the next 15 years. Joints in the right upper extremity were injected significantly (p = 0.01) more frequently than those on the left. CONCLUSION: Intrasynovial triamcinolone hexacetonide followed by rest is a very useful adjunctive modality in the treatment of seropositive rheumatoid arthritis.
D J McCarty; J G Harman; J L Grassanovich; C Qian
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  22     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1996-01-22     Completed Date:  1996-01-22     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1631-5     Citation Subset:  IM    
Department of Medicine, Medical College of Wisconsin, Milwaukee 53226, USA.
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MeSH Terms
Anti-Inflammatory Agents / administration & dosage*,  adverse effects
Arthritis, Rheumatoid / drug therapy*
Bed Rest
Combined Modality Therapy
Follow-Up Studies
Injections, Intra-Articular
Remission Induction
Treatment Outcome
Triamcinolone Acetonide / administration & dosage,  adverse effects,  analogs & derivatives*
Reg. No./Substance:
0/Anti-Inflammatory Agents; 5611-51-8/triamcinolone hexacetonide; 76-25-5/Triamcinolone Acetonide
Comment In:
J Rheumatol. 1996 Sep;23(9):1666-7   [PMID:  8877945 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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