Document Detail

[Treatment results of nasopharyngeal carcinoma in adults].
MedLine Citation:
PMID:  23202863     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Nasopharyngeal carcinoma (NPC) is a rare tumor entity in Germany in contrast to endemic countries in Asia or Africa. This retrospective study investigated patient characteristics and prognostic factors with respect to different NPC treatment strategies.
PATIENTS AND METHODS: A total of 63 NPC patients treated during the period 1990-2009 at the University Hospital Bonn, Germany, were included.
RESULTS: The median age of the patients was 56.4 years, the male:female ratio was 3.2:1, 23.8% were in Union Internationale Contre le Cancer (UICC) stage I/II and 76.2% were in stage III/IV. Most of the carcinomas were WHO type III (57.1%), followed by World Health Organization (WHO) type II (33.3%) and at last WHO type I (9.6%). The 5-year overall survival rate after concomitant chemoradiotherapy (RCT) was 75% and after radiotherapy (RT) 60%. The mortality rate increased by 3.5 times with each increase in T-stage (p ≤ 0.047). The recurrence rate (RR) after RCT was 34% and after RT alone 68% (p ≤ 0.04). Tumor ablation increased the RR significantly (p ≤ 0.047).
CONCLUSION: Combined chemotherapy and RT is an effective treatment of NPC disease and clearly superior to RT alone. Tumor ablation before RCT/RT worsens the prognosis and is now obsolete.
M Jakob; M Manz; S Herberhold; A Schröck; A O H Gerstner; H Schüller; K W G Eichhorn
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  HNO     Volume:  60     ISSN:  1433-0458     ISO Abbreviation:  HNO     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985099R     Medline TA:  HNO     Country:  Germany    
Other Details:
Languages:  ger     Pagination:  1075-81     Citation Subset:  IM    
Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde/Chirurgie, Uniklinik Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Deutschland,
Vernacular Title:
Ergebnisse beim Nasopharynxkarzinom im Erwachsenenalter.
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