| Treatment results of boron neutron capture therapy using intra-arterial administration of boron compounds for recurrent head and neck cancer. | |
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MedLine Citation:
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PMID: 18541628 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of boron neutron capture therapy (BNCT) is correlated with the density of boron in the tumour. BNCT using intra-arterial administration of boron compounds was performed for recurrent head and neck cancer. Of the five patients treated, one achieved a complete response and four achieved a partial response. There was one case of transient headache but no severe adverse effects were observed. The advantages of using an intra-arterial administration route for BNCT, which causes the selective killing of tumour cells, might offer a new option in the treatment of recurrent head and neck malignancies. These promising results require further verification and optimization of the BNCT schedule; however, dose escalation would appear to be justified because the toxicity appears to be very low. |
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Authors:
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N Fuwa; M Suzuki; Y Sakurai; K Nagata; Y Kinashi; S Masunaga; A Maruhashi; Y Imahori; T Kodaira; H Tachibana; T Nakamura; K Ono |
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Publication Detail:
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Type: Journal Article Date: 2008-06-09 |
Journal Detail:
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Title: The British journal of radiology Volume: 81 ISSN: 1748-880X ISO Abbreviation: Br J Radiol Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-04 Completed Date: 2008-10-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0373125 Medline TA: Br J Radiol Country: England |
Other Details:
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Languages: eng Pagination: 749-52 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiation Oncology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusaku, Nagoya 464-8681, Japan. nfuwa@aichi-cc.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Boron Compounds / administration & dosage* Boron Neutron Capture Therapy / methods* Carcinoma, Squamous Cell / radiotherapy* Case-Control Studies Dose-Response Relationship, Radiation Female Head and Neck Neoplasms / radiotherapy* Humans Injections, Intra-Arterial Male Middle Aged Neoplasm Recurrence, Local / radiotherapy* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Boron Compounds |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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