Document Detail


Treatment results of boron neutron capture therapy using intra-arterial administration of boron compounds for recurrent head and neck cancer.
MedLine Citation:
PMID:  18541628     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of boron neutron capture therapy (BNCT) is correlated with the density of boron in the tumour. BNCT using intra-arterial administration of boron compounds was performed for recurrent head and neck cancer. Of the five patients treated, one achieved a complete response and four achieved a partial response. There was one case of transient headache but no severe adverse effects were observed. The advantages of using an intra-arterial administration route for BNCT, which causes the selective killing of tumour cells, might offer a new option in the treatment of recurrent head and neck malignancies. These promising results require further verification and optimization of the BNCT schedule; however, dose escalation would appear to be justified because the toxicity appears to be very low.
Authors:
N Fuwa; M Suzuki; Y Sakurai; K Nagata; Y Kinashi; S Masunaga; A Maruhashi; Y Imahori; T Kodaira; H Tachibana; T Nakamura; K Ono
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Publication Detail:
Type:  Journal Article     Date:  2008-06-09
Journal Detail:
Title:  The British journal of radiology     Volume:  81     ISSN:  1748-880X     ISO Abbreviation:  Br J Radiol     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-04     Completed Date:  2008-10-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0373125     Medline TA:  Br J Radiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  749-52     Citation Subset:  AIM; IM    
Affiliation:
Department of Radiation Oncology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusaku, Nagoya 464-8681, Japan. nfuwa@aichi-cc.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Boron Compounds / administration & dosage*
Boron Neutron Capture Therapy / methods*
Carcinoma, Squamous Cell / radiotherapy*
Case-Control Studies
Dose-Response Relationship, Radiation
Female
Head and Neck Neoplasms / radiotherapy*
Humans
Injections, Intra-Arterial
Male
Middle Aged
Neoplasm Recurrence, Local / radiotherapy*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Boron Compounds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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