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Treatment of respiratory syncytial virus with palivizumab: a systematic review.
MedLine Citation:
PMID:  21080142     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: Palivizumab has proven efficacy for prophylaxis of respiratory syncytial virus (RSV) in infants with prematurity or congenital heart disease. Despite a paucity of data, palivizumab is sometimes used to prevent progression when high-risk patients present with upper respiratory tract infection (URTI) due to RSV, or as therapy when any patients present with severe lower respiratory tract infection (LRTI) caused by RSV.
METHODS: A systematic review of the literatures on the use of palivizumab as therapy for RSV was conducted. The primary outcomes were progression from URTI to LRTI and survival rates. Secondary outcomes were adverse events due to palivizumab, serum palivizumab level, and RSV concentration in respiratory secretions.
RESULTS: The search yielded 1 case report, 4 case series, and 2 randomized controlled trials (RCTs) with a total of 136 adults and children. The RCTs were not powered to look at clinical outcomes. By combining all reported clinical outcomes, 3 (12%) of 25 patients with URTI who were given palivizumab died of RSV and 5 of 88 patients with LRTI at the time of treatment died of RSV (6%). Palivizumab levels appeared to be adequate for at least 3 weeks of intravenous injection at 15 mg/kg. The therapy resulted in decreased RSV concentrations in tracheal secretions.
CONCLUSION: Larger RCTs will be required before palivizumab can be recommended as therapy for RSV in any clinical setting.
Authors:
Jia Hu; Joan L Robinson
Publication Detail:
Type:  Journal Article     Date:  2010-11-16
Journal Detail:
Title:  World journal of pediatrics : WJP     Volume:  6     ISSN:  1867-0687     ISO Abbreviation:  World J Pediatr     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101278599     Medline TA:  World J Pediatr     Country:  China    
Other Details:
Languages:  eng     Pagination:  296-300     Citation Subset:  IM    
Affiliation:
Department of Pediatrics and Stollery Children's Hospital, University of Alberta, Edmonton, Canada.
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