| Treatment of renal failure associated with multiple myeloma. Plasmapheresis, hemodialysis, and chemotherapy. | |
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MedLine Citation:
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PMID: 2183734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aims of this study were to examine in a prospective, randomized trial the efficacy of plasmapheresis in preventing irreversible renal failure in patients with multiple myeloma and to study the renal biopsy tissues from such patients. Twenty-one patients with active myeloma and progressive renal failure were randomized to one of two groups: group 1, forced diuresis and chemotherapy (10 patients), and group 2, forced diuresis, chemotherapy, and plasmapheresis (11 patients). Plasmapheresis and chemotherapy lowered the serum myeloma protein value much more rapidly than chemotherapy alone. Of 5 patients who were oliguric and undergoing dialysis at presentation, only 3 who were treated by plasmapheresis recovered. Of 16 polyuric patients, 5 in group 1 and 7 in group 2 showed improvement in renal function. The main factor that determined irreversibility of renal failure was the severity of myeloma cast formation. |
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Authors:
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W J Johnson; R A Kyle; A A Pineda; P C O'Brien; K E Holley |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Archives of internal medicine Volume: 150 ISSN: 0003-9926 ISO Abbreviation: Arch. Intern. Med. Publication Date: 1990 Apr |
Date Detail:
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Created Date: 1990-05-14 Completed Date: 1990-05-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372440 Medline TA: Arch Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 863-9 Citation Subset: AIM; IM |
Affiliation:
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Division of Nephrology, Mayo Clinic, Rochester, MN 55905. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antineoplastic Combined Chemotherapy Protocols / therapeutic use* Combined Modality Therapy Female Humans Kidney / pathology Kidney Failure, Chronic / etiology, pathology, therapy* Male Middle Aged Multiple Myeloma / complications* Myeloma Proteins / metabolism Plasmapheresis* Prospective Studies Randomized Controlled Trials as Topic Renal Dialysis* |
| Chemical | |
Reg. No./Substance:
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0/Myeloma Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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