Document Detail

Treatment of renal failure associated with multiple myeloma. Plasmapheresis, hemodialysis, and chemotherapy.
MedLine Citation:
PMID:  2183734     Owner:  NLM     Status:  MEDLINE    
The aims of this study were to examine in a prospective, randomized trial the efficacy of plasmapheresis in preventing irreversible renal failure in patients with multiple myeloma and to study the renal biopsy tissues from such patients. Twenty-one patients with active myeloma and progressive renal failure were randomized to one of two groups: group 1, forced diuresis and chemotherapy (10 patients), and group 2, forced diuresis, chemotherapy, and plasmapheresis (11 patients). Plasmapheresis and chemotherapy lowered the serum myeloma protein value much more rapidly than chemotherapy alone. Of 5 patients who were oliguric and undergoing dialysis at presentation, only 3 who were treated by plasmapheresis recovered. Of 16 polyuric patients, 5 in group 1 and 7 in group 2 showed improvement in renal function. The main factor that determined irreversibility of renal failure was the severity of myeloma cast formation.
W J Johnson; R A Kyle; A A Pineda; P C O'Brien; K E Holley
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Archives of internal medicine     Volume:  150     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-05-14     Completed Date:  1990-05-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  863-9     Citation Subset:  AIM; IM    
Division of Nephrology, Mayo Clinic, Rochester, MN 55905.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Combined Modality Therapy
Kidney / pathology
Kidney Failure, Chronic / etiology,  pathology,  therapy*
Middle Aged
Multiple Myeloma / complications*
Myeloma Proteins / metabolism
Prospective Studies
Randomized Controlled Trials as Topic
Renal Dialysis*
Reg. No./Substance:
0/Myeloma Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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