Document Detail

Treatment-related central nervous system toxicity: MR imaging evaluation with CT and clinical correlation.
MedLine Citation:
PMID:  2630849     Owner:  NLM     Status:  MEDLINE    
Thirteen patients with abnormal brain MR scans attributable to treatment-induced injury were retrospectively reviewed. All patients were treated with radiation therapy and 62% received chemotherapy. Five patients were graded as having severe white matter (WM) changes, four had moderate WM changes, and four had mild WM changes. CT was generally equivalent to MR in evaluation of severe and moderate WM abnormalities, whereas MR was superior to CT in detection of mild WM abnormalities. In general, the severity of changes depicted by MR/CT correlated with the extent of neurologic dysfunction. The most severe changes were seen in those patients treated with combination irradiation and chemotherapy.
M B Hazuka; J J Kinzie; K A Davis; D A DeBoise
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Magnetic resonance imaging     Volume:  7     ISSN:  0730-725X     ISO Abbreviation:  Magn Reson Imaging     Publication Date:    1989 Nov-Dec
Date Detail:
Created Date:  1990-05-10     Completed Date:  1990-05-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8214883     Medline TA:  Magn Reson Imaging     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  669-76     Citation Subset:  IM    
Division of Radiation Onocology, University of Colorado Health Sciences Center, Denver 80262.
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MeSH Terms
Antineoplastic Agents / adverse effects*
Brain Diseases / diagnosis*,  etiology,  radiography
Brain Neoplasms / drug therapy,  radiotherapy
Combined Modality Therapy
Magnetic Resonance Imaging*
Middle Aged
Radiation Injuries / diagnosis*,  radiography
Retrospective Studies
Tomography, X-Ray Computed*
Reg. No./Substance:
0/Antineoplastic Agents

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