Document Detail


Treatment of refractory sarcoidal parotid gland swelling in a previously reported unresponsive case.
MedLine Citation:
PMID:  16196234     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Sarcoidosis is a multisystem granulomatous disease that is seen occasionally in patients with characteristic bilateral parotid gland swelling. Conventional therapy has involved either no treatment because of spontaneous remission or corticosteroids when organ involvement is severe. CASE DESCRIPTION: The authors describe a previously published case report of a patient with sarcoidosis with parotid gland swellings who did not respond to standard therapy. Despite the use of various immunosuppressive agents, the swellings failed to resolve over a three-year period. It was only after a newly recommended agent, infliximab, was used that the patient's condition was treated successfully. CLINICAL IMPLICATIONS: It is important for dental practitioners to be familiar with manifestations of sarcoidosis, particularly its salivary gland aspects. Inherent in the knowledge of the disease is the therapeutic approach to both routine and recalcitrant
Authors:
Louis Mandel; Barry Wolinsky; Elizabeth C Chalom
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the American Dental Association (1939)     Volume:  136     ISSN:  0002-8177     ISO Abbreviation:  J Am Dent Assoc     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-10-03     Completed Date:  2005-11-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503060     Medline TA:  J Am Dent Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1282-5     Citation Subset:  D; IM    
Affiliation:
Salivary Gland Center, School of Dental and Oral Surgery, Columbia University, New York, NY 10032, USA. LM7@Columbia.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Antibodies, Monoclonal / therapeutic use
Female
Follow-Up Studies
Humans
Immunosuppressive Agents / therapeutic use*
Parotid Diseases / drug therapy*
Recurrence
Remission Induction
Sarcoidosis / drug therapy*
Tumor Necrosis Factor-alpha / immunology*
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Immunosuppressive Agents; 0/Tumor Necrosis Factor-alpha; 0/infliximab

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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