Document Detail

Treatment-refractory obsessive-compulsive disorder: methodological issues, operational definitions and therapeutic lines.
MedLine Citation:
PMID:  16503369     Owner:  NLM     Status:  MEDLINE    
While controlled trials with SRIs have demonstrated a selective efficacy in obsessive-compulsive disorder (OCD), up to 40-60% of patients do not have a satisfactory outcome. Non-response to treatment in OCD is associated with serious social disability. There are a large number of non-responsive patients, and they are difficult to cluster due to ambiguities in diagnostic criteria, possibility of subtypes and a high rate of comorbidity. Moreover, the findings of current studies of "so-called" non-responsive cases are currently non-generalizable because of the lack of an operational definition of non-response. The result has been that a cumulative body of data on a reasonably homogeneous sample of non-responders has not been developed. The aims of the research in this area are to clarify some of the obstacles in defining stages of response and levels of non-response and, through a comprehensive analysis, to propose a systematic nosology for this rather common condition. Better characterization of which patients respond and do not respond to various treatments will enable more accurate clustering of patients, and help facilitate multisite data collection for future research trials. The authors reviewed also the more recent therapeutic pharmacological and psychological lines for the treatment of refractoriness in OCD.
Stefano Pallanti; Leonardo Quercioli
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-02-28
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  30     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-21     Completed Date:  2006-07-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  400-12     Citation Subset:  IM    
Mount Sinai School of Medicine, New York, New York, USA.
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MeSH Terms
Combined Modality Therapy
Drug Resistance
Obsessive-Compulsive Disorder / classification,  diagnosis,  epidemiology,  therapy*
Psychotherapy / methods*
Psychotropic Drugs / therapeutic use*
Serotonin Uptake Inhibitors / therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Psychotropic Drugs; 0/Serotonin Uptake Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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