Document Detail

Treatment of refractory mesenteric traction syndrome without cyclooxygenase inhibitors.
MedLine Citation:
PMID:  15590261     Owner:  NLM     Status:  MEDLINE    
Mesenteric traction may be necessary for surgical exposure during colonic or aortic surgery. Traction on the mesentery releases prostacyclin, producing variable degrees of hypotension. Numerous cases of severe, life-threatening hypotension have been reported. The published literature suggests that treatment of severe hypotension from mesenteric traction with routine doses of vasoconstrictors may be ineffective, but inhibition of prostacyclin synthesis with cyclooxygenase inhibitors can successfully treat or prevent hypotension. This rationale, while highly beneficial, would place patients with allergies to cyclooxygenase inhibitors at a severe disadvantage, and would also leave no therapeutic options if intravenous cyclooxygenase inhibitors were not immediately available. We report the successful use of high-dose phenylephrine in the treatment of mesenteric traction syndrome.
Harvey Woehlck; Mursel Antapli; Anuradha Mann
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of clinical anesthesia     Volume:  16     ISSN:  0952-8180     ISO Abbreviation:  J Clin Anesth     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-12-13     Completed Date:  2005-07-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8812166     Medline TA:  J Clin Anesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  542-4     Citation Subset:  IM    
Department of Anesthesiology, Froedtert Memorial Lutheran Hospital West, Milwaukee, WI 53226, USA.
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MeSH Terms
Colitis, Ulcerative / etiology,  surgery
Digestive System Surgical Procedures / adverse effects*,  methods
Hypotension / drug therapy*,  etiology
Intraoperative Complications / drug therapy,  etiology
Middle Aged
Phenylephrine / therapeutic use*
Vasoconstrictor Agents / therapeutic use*
Reg. No./Substance:
0/Vasoconstrictor Agents; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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