Document Detail

Treatment of refractory cardiac allograft rejection with OKT3 monoclonal antibody.
MedLine Citation:
PMID:  3544838     Owner:  NLM     Status:  MEDLINE    
OKT3 monoclonal antibody is a murine monoclonal antibody specific for the T lymphocyte T3 cell surface receptor that mediates antigen recognition. The use of OKT3 monoclonal antibody for the treatment of cardiac allograft rejection refractory to conventional therapy with high-dose steroids and antithymocyte globulin is described. Seven patients received 5 mg of OKT3 monoclonal antibody intravenously per day for 10 to 14 days. Diagnosis of moderate or severe rejection was made in all seven from right ventricular endomyocardial biopsy. Biopsy was repeated 48 to 72 hours and seven to 10 days after OKT3 monoclonal antibody was begun. With treatment, four patients had a complete response, with improvement on both early and late biopsy. Two patients had partial responses, with improvement on early biopsy followed by worsening rejection on late biopsy. One patient died of graft failure six hours after receiving OKT3 monoclonal antibody. Adverse events were common in the first two days of therapy but were well tolerated. It is concluded that OKT3 monoclonal antibody is useful in the treatment of refractory cardiac allograft rejection.
E M Gilbert; C W Dewitt; C C Eiswirth; D G Renlund; R L Menlove; L A Freedman; C M Herrick; W A Gay; M R Bristow
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of medicine     Volume:  82     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-03-17     Completed Date:  1987-03-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  202-6     Citation Subset:  AIM; IM    
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MeSH Terms
Antibodies, Monoclonal / therapeutic use*
Graft Rejection*
Heart Transplantation*
Leukocyte Count
Middle Aged
Myocardium / immunology,  pathology
T-Lymphocytes / classification,  immunology
Reg. No./Substance:
0/Antibodies, Monoclonal

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