| Treatment of reflux-related and non-reflux-related dysphonia with profound gastric acid inhibition. | |
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MedLine Citation:
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PMID: 11014938 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thirty-eight patients with dysphonia exceeding 3 months, not caused by trauma, infection, paralysis or allergy, were studied. In all patients a 24-hour ambulatory dual-probe pH monitoring, 5 and 20 cm above the lower oesophageal sphincter was performed. Subsequently they were treated with lansoprazole 30 mg once daily during 6 weeks. A voice range profile, perceptual evaluation of the voice and videolaryngostroboscopy were performed in all patients before and after treatment. A questionnaire about laryngeal symptoms and heartburn was completed on the same two occasions. Thirty-nine percent (15 out of 38) of the patients had an abnormal pH profile and were considered to have reflux-related dysphonia. Only these patients showed a significant improvement in their subjective score on dysphonia (p < 0.05), chronic cough (p < 0.05), dysphagia (p < 0. 05) and heartburn (p < 0.01). Also posterior erythema decreased significantly in these patients (p < 0.01). Only 2 of the 15 subjects did not complain of heartburn. |
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Authors:
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L H Willems-Bloemer; G C Vreeburg; R Brummer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP) Volume: 52 ISSN: 1021-7762 ISO Abbreviation: Folia Phoniatr Logop Publication Date: 2000 Nov-Dec |
Date Detail:
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Created Date: 2000-12-15 Completed Date: 2000-12-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9422792 Medline TA: Folia Phoniatr Logop Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 289-94 Citation Subset: IM |
Affiliation:
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Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University Hospital, Maastricht, The Netherlands. l.willems@kno.azm.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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2-Pyridinylmethylsulfinylbenzimidazoles Adult Aged Anti-Ulcer Agents / pharmacology*, therapeutic use* Female Gastric Acid / metabolism* Gastroesophageal Reflux / complications*, drug therapy* Humans Male Middle Aged Omeprazole / analogs & derivatives*, pharmacology*, therapeutic use* Severity of Illness Index Treatment Outcome Voice Disorders / diagnosis, drug therapy*, etiology* |
| Chemical | |
Reg. No./Substance:
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0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Anti-Ulcer Agents; 103577-45-3/lansoprazole; 73590-58-6/Omeprazole |
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