Document Detail

Treatment of recurrent ventricular tachycardias using oral propafenone
MedLine Citation:
PMID:  3938260     Owner:  NLM     Status:  MEDLINE    
The effect of oral propafenone on prevention of pacing-induced ventricular tachycardia (VT) was studied in 11 patients. All patients experienced documented sustained VT refractory to 4.1 +/- 2 antiarrhythmic agents per patient including amiodarone in 8. Programmed electrical stimulation was performed before and 48-72 hours after oral propafenone (900 mg/day) 2-3 hours after the last dose. Two patients developed spontaneous incessant VT before the scheduled date of the study on propafenone, and were classified as aggravation. Propafenone prevented pacing-induced VT in 2 patients (successful results). In 3 additional patients the results were partial, as non-sustained VT was induced on propafenone whereas sustained VT could be provoked during the control study. In the remaining 4 patients, oral propafenone failed to prevent pacing-induced VT. Tachycardia cycle length increased in 3 (C = 284 +/- 129 P = 450 +/- 202 ms) and was shorter in 1 aggravation. The 5 patients with successful or partial results (45.4 p. cent), underwent long-term therapy with a mean follow up of 5.6 +/- 4 months. Recurrence of VT occurred in 2. The remaining 3 are well controlled. This study demonstrates that propafenone is able to prevent pacing-induced VT in a limited number of patients. Stimulation techniques are useful in order to detect patients with potential pro-arrhythmic effect.
R Cointe; S Lévy; M Metge; F Vrancea; P Labrunie; B Valeix; R Gérard
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Archives des maladies du coeur et des vaisseaux     Volume:  78 Spec No     ISSN:  0003-9683     ISO Abbreviation:  Arch Mal Coeur Vaiss     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1986-04-04     Completed Date:  1986-04-04     Revised Date:  2009-02-13    
Medline Journal Info:
Nlm Unique ID:  0406011     Medline TA:  Arch Mal Coeur Vaiss     Country:  FRANCE    
Other Details:
Languages:  fre     Pagination:  59-62     Citation Subset:  IM    
Vernacular Title:
Traitement des tachycardies ventriculaires récidivantes par la propafénone orale.
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MeSH Terms
Administration, Oral
Anti-Arrhythmia Agents / therapeutic use*
Electric Stimulation
Heart Conduction System / physiopathology
Heart Ventricles
Middle Aged
Propiophenones / administration & dosage,  therapeutic use*
Prospective Studies
Tachycardia / drug therapy*,  physiopathology
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Propiophenones; 54063-53-5/Propafenone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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