| Treatment of rats with monoclonal anti-CD4 induces long-term resistance to streptococcal cell wall-induced arthritis. | |
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MedLine Citation:
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PMID: 1730259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the role of CD4+ cells in the induction and maintenance of streptococcal cell wall (SCW)-induced arthritis, Lewis rats were treated with a monoclonal antibody against rat CD4 (W3/25). Injection before onset of the arthritis resulted in resistance to SCW arthritis. Treatment with anti-CD4 during ongoing arthritis induced an amelioration of the arthritis, demonstrating that CD4+ cells are involved in both the induction and effector phases of the chronic arthritis. After return of CD4+ cells to normal levels in the circulation, no arthritis occurred in protected rats, despite the continued presence of SCW in the body. Even reinjection of SCW could not induce arthritis in these rats, suggesting that tolerance to SCW had occurred. In addition, these tolerized rats were refractory to actively induced adjuvant arthritis (AA), but were susceptible to passively transferred AA. Our data imply, that (a) treatment with anti-CD4 plus SCW induces a long-term resistance to SCW-induced arthritis and adjuvant arthritis, (b) SCW and M. tuberculosis may use similar mechanisms of regulation of arthritis and (c) active peripheral suppression is not the mechanism of this nonresponsiveness. |
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Authors:
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M F Van den Broek; L G Van de Langerijt; M C Van Bruggen; M E Billingham; W B Van den Berg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of immunology Volume: 22 ISSN: 0014-2980 ISO Abbreviation: Eur. J. Immunol. Publication Date: 1992 Jan |
Date Detail:
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Created Date: 1992-02-18 Completed Date: 1992-02-18 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1273201 Medline TA: Eur J Immunol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 57-61 Citation Subset: IM |
Affiliation:
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Department of Rheumatology, University Hospital Nijmegen, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Monoclonal / immunology* Antigens, CD4 / immunology* Arthritis / immunology* Arthritis, Experimental / immunology Autoimmune Diseases / immunology Cell Wall / immunology Female Rats Rats, Inbred Lew Streptococcus / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Antigens, CD4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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