Document Detail

Treatment of pulmonary melioidosis with combination of trimethoprim and sulfamethoxazole.
MedLine Citation:
PMID:  679759     Owner:  NLM     Status:  MEDLINE    
Treatment with a combination of trimethoprim and sulfamethoxazole proved lifesaving in a patient with pulmonary melioidosis after therapeutic failure occurred with other antibiotics to which the organisms were sensitive in vitro. Antagonistic interaction of drugs occurred when the combination of trimethoprim and sulfamethoxazole was given along with other antibiotics. The combination of trimethoprim and sulfamethoxazole should be considered a major addition to the pharmacologic armamentarium for the treatment of pulmonary melioidosis.
P B Fuller; D E Fisk; R B Byrd; G A Griggs; M R Smith
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Chest     Volume:  74     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1978 Aug 
Date Detail:
Created Date:  1978-10-25     Completed Date:  1978-10-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  222-4     Citation Subset:  AIM; IM    
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MeSH Terms
Asia, Southeastern
Drug Combinations
Lung Diseases / drug therapy*
Melioidosis / drug therapy*
Sulfamethoxazole / administration & dosage*,  therapeutic use
Trimethoprim / administration & dosage*,  therapeutic use
Reg. No./Substance:
0/Drug Combinations; 723-46-6/Sulfamethoxazole; 738-70-5/Trimethoprim

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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