Document Detail

Treatment of psychotic disorders with aripiprazole in the emergency psychiatric setting.
MedLine Citation:
PMID:  18827757     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the effectiveness of aripiprazole in the treatment of patients with psychotic symptoms in the emergency psychiatric setting.
SUBJECTS AND METHODS: We considered all patients admitted to a psychiatric intensive care unit of a general hospital in a two year-period, treated with at least one dose of aripiprazole. We measured 1) the rate of cases starting aripiprazole who did not change antipsychotic in the course of hospitalization; 2) the rate of cases who were concurrently treated with another antipsychotic; 3) the CGI Improvement score.
RESULTS: In 63 cases, aripiprazole was started on admission. Forty-nine (77.7%) of these cases were treated with aripiprazole also on discharge. Among the 63 cases who started aripiprazole on admission, 22 (34.9%) were concurrently treated with another antipsychotic. Among the 53 cases discharged with aripiprazole, 15 (28.3%) were concurrently treated with another antipsychotic. Of the 49 cases treated with aripiprazole both on admission and on discharge, 24 cases were much improved, 11 cases moderately improved, 10 cases mildly improved, and 4 cases were not improved at the CGI Improvement Score.
CONCLUSIONS: Aripiprazole should be considered as first line treatment in some patients affected by psychotic disorders visited in the emergency psychiatric setting.
Michele Raja; Antonella Azzoni
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Psychiatria Danubina     Volume:  20     ISSN:  0353-5053     ISO Abbreviation:  Psychiatr Danub     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-10-01     Completed Date:  2008-11-12     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  9424753     Medline TA:  Psychiatr Danub     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  323-8     Citation Subset:  IM    
Servizio Psichiatrico di Diagnosi e Cura, Ospedale Santo Spirito in Sassia, Rome, Italy.
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MeSH Terms
Acute Disease
Antipsychotic Agents / therapeutic use*
Clozapine / therapeutic use
Diagnostic and Statistical Manual of Mental Disorders
Dibenzothiazepines / therapeutic use
Drug Therapy, Combination
Emergency Services, Psychiatric / statistics & numerical data*
Intensive Care Units / statistics & numerical data
Middle Aged
Piperazines / therapeutic use*
Psychiatric Department, Hospital / statistics & numerical data
Psychiatric Status Rating Scales / statistics & numerical data
Psychotic Disorders / drug therapy*,  psychology
Quinolones / therapeutic use*
Risperidone / therapeutic use
Schizophrenia / drug therapy
Severity of Illness Index
Treatment Outcome
Reg. No./Substance:
0/Antipsychotic Agents; 0/Dibenzothiazepines; 0/Piperazines; 0/Quinolones; 106266-06-2/Risperidone; 5786-21-0/Clozapine; 82VFR53I78/aripiprazole; BGL0JSY5SI/quetiapine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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