Document Detail

Treatment of prolymphocytic leukemia with cladribine.
MedLine Citation:
PMID:  9540763     Owner:  NLM     Status:  MEDLINE    
Prolymphocytic leukemia (PLL) is a rare lymphoproliferative disorder that takes a rapidly progressive course and where therapeutic interventions are often unsuccessful. In this context, the new purine analogs may be a promising option. We report two cases of PLL treated with cladribine. The first patient had been resistant to polychemotherapy (COP) but responded well to two courses of 2-CdA. He achieved a partial remission, which he maintained for 15 months. The second patient had very advanced disease but obtained a partial response after three courses of 2-CdA, given as a first-line therapy in an ambulatory setting. These results, as well others reported in the literature, permit us to consider 2-CdA as a highly promising therapeutic option for PLL.
I Lorand-Metze; G B Oliveira; F J Aranha
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of hematology     Volume:  76     ISSN:  0939-5555     ISO Abbreviation:  Ann. Hematol.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-04-23     Completed Date:  1998-04-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9107334     Medline TA:  Ann Hematol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  85-6     Citation Subset:  IM    
Department of Internal Medicine, Faculty of Medicine, Brazil.
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MeSH Terms
Antineoplastic Agents / therapeutic use*
Cladribine / therapeutic use*
Leukemia, Prolymphocytic / drug therapy*
Remission Induction
Reg. No./Substance:
0/Antineoplastic Agents; 4291-63-8/Cladribine

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