| Treatment of prolymphocytic leukemia with cladribine. | |
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MedLine Citation:
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PMID: 9540763 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prolymphocytic leukemia (PLL) is a rare lymphoproliferative disorder that takes a rapidly progressive course and where therapeutic interventions are often unsuccessful. In this context, the new purine analogs may be a promising option. We report two cases of PLL treated with cladribine. The first patient had been resistant to polychemotherapy (COP) but responded well to two courses of 2-CdA. He achieved a partial remission, which he maintained for 15 months. The second patient had very advanced disease but obtained a partial response after three courses of 2-CdA, given as a first-line therapy in an ambulatory setting. These results, as well others reported in the literature, permit us to consider 2-CdA as a highly promising therapeutic option for PLL. |
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Authors:
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I Lorand-Metze; G B Oliveira; F J Aranha |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of hematology Volume: 76 ISSN: 0939-5555 ISO Abbreviation: Ann. Hematol. Publication Date: 1998 Feb |
Date Detail:
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Created Date: 1998-04-23 Completed Date: 1998-04-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9107334 Medline TA: Ann Hematol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 85-6 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Faculty of Medicine, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antineoplastic Agents / therapeutic use* Cladribine / therapeutic use* Humans Leukemia, Prolymphocytic / drug therapy* Male Remission Induction |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 4291-63-8/Cladribine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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