Document Detail

Treatment of primary dysmenorrhea with diclofenac sodium.
MedLine Citation:
PMID:  7028529     Owner:  NLM     Status:  MEDLINE    
The efficacy of diclofenac sodium was investigated in the painful symptoms of primary dysmenorrhea and in reducing menstrual bleeding. Thirty-five nulliparous women (17-28 yr of age) were included in a double-blind cross-over study for four menstrual periods, two periods with diclofenac sodium and two periods with placebo. The diclofenac sodium treatment (total of 58 periods) reduced the pain significantly in comparison with placebo (57 periods), as evaluated by subjective rating (P less than 0.001) and by a 6-point scale of pain intensity (P less than 0.05). Also the amount of menstrual bleeding was significantly reduced as measured by subjective rating (P less than 0.001) and by counting the number of sanitary pads used (P less than 0.05). The results indicate that diclofenac sodium in low dose (about 75 mg daily) is effective not only in reducing the pain at menstruation, but also the bleeding.
P Riihiluoma; E Wuolijoki; M O Pulkkinen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  12     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  1981 Sep 
Date Detail:
Created Date:  1982-01-20     Completed Date:  1982-01-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  189-94     Citation Subset:  IM    
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MeSH Terms
Clinical Trials as Topic
Diclofenac / therapeutic use*
Double-Blind Method
Dysmenorrhea / drug therapy*
Pain / drug therapy
Phenylacetates / therapeutic use*
Random Allocation
Reg. No./Substance:
0/Phenylacetates; 15307-86-5/Diclofenac

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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