| Treatment of primary biliary cirrhosis. | |
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MedLine Citation:
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PMID: 16498378 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Primary biliary cirrhosis is a chronic liver disease of unknown etiology, characterized by inflammation and destruction of the intrahepatic biliary ducts, resulting in chronic cholestasis and eventually cirrhosis. The main clinical manifestations consists of pruritus, jaundice, xanthomas, and the consequences of intestinal malabsorption, including vitamin deficiencies and osteodystrophy. Treatment of PBC is addressed at preventing or relieving the symptoms and clinical consequences of chronic cholestasis, and also at correcting the bile duct abnormalities by specific treatments. Pruritus is treated with cholestyramine, but in some cases other drugs, such as rifampicin or opioid antagonists are needed. Bisphosphanates are effective for increasing bone mass in osteopenic patients. Vitamin D and cAlcium supplements are also recommended, particularly in patients with severe cholestasis. Ursodeoxycholic acid (UDCA) has become the standard treatment (13-15 mg/kg/day), resulting in marked relieving of cholestasis. UDCA also prevents the histological progression of the disease, although the effects on survival are less apparent. Small trials of combination therapy using UDCA with methotrexate, colchicine, or prednisone, have been reported but have not shown any increased efficacy over UDCA therapy. Liver transplantation is the only treatment available when cholestasis progresses, with very good survival rates. |
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Authors:
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A Parés; J Rodés |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Minerva gastroenterologica e dietologica Volume: 46 ISSN: 1121-421X ISO Abbreviation: Minerva Gastroenterol Dietol Publication Date: 2000 Sep |
Date Detail:
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Created Date: 2006-02-24 Completed Date: 2006-03-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9109791 Medline TA: Minerva Gastroenterol Dietol Country: Italy |
Other Details:
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Languages: eng Pagination: 165-74 Citation Subset: - |
Affiliation:
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Liver Unit, Institut de Malaties Digestives, Hospital Clinic IDIBAPS, University of Barcelona, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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