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Treatment of preterm infants with West syndrome: differences due to etiology.
MedLine Citation:
PMID:  22882769     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: This study was conducted with a particular focus on preterm infants with West syndrome (WS) to evaluate differences in the first responses to oral medication based on their etiology. PATIENTS AND METHODS: Medical records of 53 patients with WS, treated at five institutions between 2005 and 2009, were reviewed retrospectively. Patients were divided into six groups based on the time of their brain insult, and evaluated for short-term outcomes using oral antiepileptic agents and synthetic adrenocorticotropic hormone. RESULTS: Patients numbering 15, 6, 14, 2, 4, and 12 were placed into prenatal, term, preterm, postnatal, other, and no identified etiology groups respectively. The average age of onset in the term group was 3.3 ± 1.0 months, significantly earlier than for all other groups (p < 0.05). All patients in the term group had experienced seizures before the onset of WS. Only patients in the preterm group had experienced neonatal seizures and exhibited better responses to treatment, especially oral medication, compared with those in the prenatal and term groups. The percentage of cases involving relapse of seizures in the preterm group (14%) was significantly lower than that in the prenatal group. CONCLUSIONS: Preterm WS patients responded well to treatment. Distinguishing WS patients on the basis of different etiologies is important for evaluating the effectiveness of treatments.
Authors:
Takeo Mure; Taku Nakagawa; Yo Okizuka; Yuuichi Takami; Yoshinobu Oyazato; Hiroaki Nagase; Azusa Maruyama; Masao Adachi; Satoshi Takada; Masafumi Matsuo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-13
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  -     ISSN:  1442-200X     ISO Abbreviation:  Pediatr Int     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society.
Affiliation:
Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
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