Document Detail

Treatment of premenstrual mastalgia with tamoxifen.
MedLine Citation:
PMID:  3051879     Owner:  NLM     Status:  MEDLINE    
Thirty-four women with normal menstrual cycles but suffering from severe premenstrual mastalgia were randomly treated with either tamoxifen (10 mg daily) (18 women) or placebo (16 women) from cycle day 5 to 24 for six consecutive cycles. At the end of the treatment, 89% of the tamoxifen-treated patients were free from the symptoms and the remainder experienced partial alleviation. In contrast, six patients treated with placebo showed only partial alleviation (38%) (p less than 0.001). Twelve months after the end of tamoxifen treatment, 53% of the medicated women were still free of symptoms as compared with none of the placebo-treated patients. These results suggest that tamoxifen is highly effective for the management of severe premenstrual mastalgia and should be useful for the treatment of this disorder.
I E Messinis; D Lolis
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  67     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  1988  
Date Detail:
Created Date:  1988-11-15     Completed Date:  1988-11-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  307-9     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Ioannina, Greece.
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MeSH Terms
Breast / drug effects*
Clinical Trials as Topic
Pain / drug therapy*
Premenstrual Syndrome / drug therapy*
Random Allocation
Tamoxifen / administration & dosage*
Reg. No./Substance:

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