Document Detail

Treatment of premature ejaculation by glans penis augmentation using hyaluronic acid gel: a pilot study.
MedLine Citation:
PMID:  22013959     Owner:  NLM     Status:  MEDLINE    
Premature ejaculation (PE) is by far the most common male sexual complaint, with millions of men affected all over the world. It is estimated that up to 20-30% of all men may be suffering from various forms of PE. A variety of filler materials are widely used nowadays for soft tissue augmentation. The appropriate filler can restore symmetry, volume and create a smooth skin surface The aim of this pilot study was to evaluate the therapeutic effect of hyaluronic acid gel injection in patients with PE. Sixty men with self-reported PE who were referred to our outpatient andrology clinic (between January 2007 and January 2008) were included in this study. Participants were randomly assigned using random sampling numbers into two distinct groups. Group A (n = 30) received a single injection of 2 ml of hyaluronic acid gel (Hyalift 3.5% micronised hyaluronic acid) using the previously described fan technique. Group B (n = 30) received a single injection of 2 ml of hyaluronic acid gel using the multiple puncture technique. Twenty-three patients (46.9%) received injection by the fan technique, while 26 patients (53.1%) received it through the multiple-point technique. The mean intravaginal ejaculation latency time (IELT) increased significantly from 2.12 ± 1.16 to 7.71 ± 7.86 min, after 1 month of injection and then dropped to 5.32 ± 3.52 min, but still remaining significantly higher than the baseline values. Results from our present pilot study demonstrated the usefulness of the application of hyaluronic acid dermal fillers in the treatment of PE; however, further investigations in large cohorts with longer follow-up are definitely needed to obtain more consistent results.
H Abdallah; T Abdelnasser; H Hosny; O Selim; A Al-Ahwany; R Shamloul
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2011-10-20
Journal Detail:
Title:  Andrologia     Volume:  44 Suppl 1     ISSN:  1439-0272     ISO Abbreviation:  Andrologia     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-25     Completed Date:  2012-09-27     Revised Date:  2012-11-11    
Medline Journal Info:
Nlm Unique ID:  0423506     Medline TA:  Andrologia     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  650-3     Citation Subset:  IM    
Copyright Information:
© 2011 Blackwell Verlag GmbH.
Andrology Department, Cairo University, Cairo, Egypt.
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MeSH Terms
Hyaluronic Acid / administration & dosage*
Middle Aged
Pilot Projects
Sexual Dysfunction, Physiological / therapy*
Reg. No./Substance:
9004-61-9/Hyaluronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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