Document Detail

Treatment of precocious puberty in a female with Prader-Willi syndrome.
MedLine Citation:
PMID:  18655533     Owner:  NLM     Status:  MEDLINE    
Prader-Willi syndrome (PWS) is characterized by neonatal hypotonia, hyperphagia, childhood obesity at an early age, short stature, varying degrees of mental deficiency, and hypogonadism. In PWS, puberty is usually delayed and fails to complete, with most females never having regular menstrual cycles. We report a female patient with uniparental disomy, who experienced precocious puberty with menarche at age 8 years. The patient was treated with luteinizing hormone releasing hormone (LHRH) analog, which suppressed pubertal development. From our search of the literature this is the first application of LHRH analog to a female PWS patient for precocious puberty. Use of LHRH analog along with recombinant human growth hormone (rhGH) permitted stature closer to target height. The clinical course of this patient with PWS underscores the need for individualized treatment.
Erin Rose Pusz; Deborah Rotenstein
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  21     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-07-28     Completed Date:  2008-08-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  495-500     Citation Subset:  IM    
Lake Erie College of Osteopathic Medicine, Erie, PA, USA.
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MeSH Terms
Gonadotropin-Releasing Hormone / analogs & derivatives*
Prader-Willi Syndrome / complications*
Puberty, Precocious / drug therapy*,  etiology*
Treatment Outcome
Reg. No./Substance:
33515-09-2/Gonadotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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