| Treatment of postmenopausal hypertension with moxonidine, a selective imidazoline receptor agonist. | |
MedLine Citation:
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PMID: 15117110 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study compared the effects of two sympatholytic agents--one central (moxonidine) and one peripheral (atenolol)--on blood pressure and other metabolic syndrome factors in postmenopausal hypertensive women who were not taking hormone replacement therapy. Atenolol and moxonidine led to a statistically significant reduction in diastolic blood pressure of 9.5 mmHg and 5.5 mmHg, respectively. A clear rebound effect was observed in the atenolol patients whereas the moxonidine group exhibited a slightly further decrease in blood pressure. Moxonidine also caused a profound decrease in both mean plasma-glucose area under the curve (AUC) during oral glucose tolerance test (-0.96 mmol/L x H, NS) and mean plasma-insulin AUC (-6.15 mU/L x H). Therefore, moxonidine displayed a slightly less potent antihypertensive effect than atenolol in hypertensive postmenopausal women, but it demonstrated a better metabolic effect. To conclude, moxonidine could benefit hypertensive postmenopausal women who display other signs of metabolic syndrome. |
Authors:
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Risto Kaaja; Karin Manhem; Jaakko Tuomilehto |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of clinical practice. Supplement Volume: - ISSN: 1368-504X ISO Abbreviation: Int J Clin Pract Suppl Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-04-30 Completed Date: 2004-10-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9712380 Medline TA: Int J Clin Pract Suppl Country: England |
Other Details:
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Languages: eng Pagination: 26-32 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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therapeutic use* Atenolol / therapeutic use* Blood Glucose / analysis Double-Blind Method Female Humans Hypertension / drug therapy*, metabolism Imidazoles / therapeutic use* Imidazoline Receptors Insulin / blood Middle Aged Postmenopause* Prospective Studies Receptors, Drug / metabolism Sympatholytics / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Blood Glucose; 0/Imidazoles; 0/Imidazoline Receptors; 0/Receptors, Drug; 0/Sympatholytics; 11061-68-0/Insulin; 29122-68-7/Atenolol; 75438-57-2/moxonidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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