Document Detail


Treatment of postmastectomy lymphedema with low-level laser therapy: a double blind, placebo-controlled trial.
MedLine Citation:
PMID:  12973834     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The current study describes the results of a double blind, placebo-controlled, randomized, single crossover trial of the treatment of patients with postmastectomy lymphedema (PML) with low-level laser therapy (LLLT). METHODS: Participants received placebo or one cycle or two cycles of LLLT to the axillary region of their affected arm. They were monitored for reductions in affected limb volume, upper body extracellular tissue fluid distribution, dermal tonometry, and range of limb movement. RESULTS: There was no significant improvement reported immediately after any of the treatments. However, the mean affected limb volume was found to be significantly reduced at 1 month or 3 months of follow-up after 2 cycles of active laser treatment. Approximately 31% of subjects had a clinically significant reduction in the volume of their PML-affected arm (> 200 mLs) approximately 2-3 months after 2 cycles of treatment. There was no significant effect of placebo treatment, or one cycle of laser treatment, on affected limb volume. The extracellular fluid index of the affected and unaffected arms and torso were reported to be significantly reduced at 3 months after 2 cycles of laser therapy, and there was significant softening of the tissues in the affected upper arm. Treatment did not appear to improve range of movement of the affected arm. CONCLUSIONS: Two cycles of laser treatment were found to be effective in reducing the volume of the affected arm, extracellular fluid, and tissue hardness in approximately 33% of patients with postmastectomy lymphedema at 3 months after treatment.
Authors:
Colin J Carati; Sandy N Anderson; Bren J Gannon; Neil B Piller
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer     Volume:  98     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-15     Completed Date:  2003-09-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1114-22     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2003 American Cancer Society.DOI 10.1002/cncr.11641
Affiliation:
Department of Anatomy, School of Medicine, Flinders University, Adelaide, South Australia, Australia. colin.carati@flinders.edu.au
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Axilla
Breast Neoplasms / surgery
Cross-Over Studies
Double-Blind Method
Extracellular Space
Female
Humans
Laser Therapy, Low-Level* / methods
Lymphedema / etiology,  radiotherapy*
Mastectomy*
Middle Aged
Postoperative Complications
Tonometry, Ocular
Comments/Corrections
Erratum In:
Cancer. 2003 Dec 15;98(12):2742

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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