Document Detail

Treatment of postmastectomy lymphedema with low-level laser therapy: a double blind, placebo-controlled trial.
MedLine Citation:
PMID:  12973834     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The current study describes the results of a double blind, placebo-controlled, randomized, single crossover trial of the treatment of patients with postmastectomy lymphedema (PML) with low-level laser therapy (LLLT). METHODS: Participants received placebo or one cycle or two cycles of LLLT to the axillary region of their affected arm. They were monitored for reductions in affected limb volume, upper body extracellular tissue fluid distribution, dermal tonometry, and range of limb movement. RESULTS: There was no significant improvement reported immediately after any of the treatments. However, the mean affected limb volume was found to be significantly reduced at 1 month or 3 months of follow-up after 2 cycles of active laser treatment. Approximately 31% of subjects had a clinically significant reduction in the volume of their PML-affected arm (> 200 mLs) approximately 2-3 months after 2 cycles of treatment. There was no significant effect of placebo treatment, or one cycle of laser treatment, on affected limb volume. The extracellular fluid index of the affected and unaffected arms and torso were reported to be significantly reduced at 3 months after 2 cycles of laser therapy, and there was significant softening of the tissues in the affected upper arm. Treatment did not appear to improve range of movement of the affected arm. CONCLUSIONS: Two cycles of laser treatment were found to be effective in reducing the volume of the affected arm, extracellular fluid, and tissue hardness in approximately 33% of patients with postmastectomy lymphedema at 3 months after treatment.
Colin J Carati; Sandy N Anderson; Bren J Gannon; Neil B Piller
Related Documents :
15008864 - Er:yag laser treatment of verrucous epidermal nevi.
25307004 - Antibiotic coated catheter to decrease infection: pilot study.
1530264 - Percutaneous photocoagulation of deep vascular lesions using a fiberoptic laser wand.
15023284 - Transmyocardial laser revascularization.
20216394 - Cognitive function after major noncardiac surgery, apolipoprotein e4 genotype, and biom...
7809344 - Effect of short-term cognitive psychotherapy on recurrence of duodenal ulcer: a prospec...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer     Volume:  98     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-15     Completed Date:  2003-09-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1114-22     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2003 American Cancer Society.DOI 10.1002/cncr.11641
Department of Anatomy, School of Medicine, Flinders University, Adelaide, South Australia, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Breast Neoplasms / surgery
Cross-Over Studies
Double-Blind Method
Extracellular Space
Laser Therapy, Low-Level* / methods
Lymphedema / etiology,  radiotherapy*
Middle Aged
Postoperative Complications
Tonometry, Ocular
Erratum In:
Cancer. 2003 Dec 15;98(12):2742

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of age on prognosis with imatinib mesylate therapy for patients with Philadelphia chromosome...
Next Document:  ErbB2 overexpression in human breast carcinoma is correlated with p21Cip1 up-regulation and tyrosine...